A rare case of lysozyme-induced anaphylaxis in a child with egg allergy

IF 1.3 4区 医学 Q3 PEDIATRICS
Charles Elbany , Delphine de Boissieu , Chantal Karila , Marie-Alexandra Alyanakian , Claude Ponvert , Florence Lageix , Guillaume Lezmi
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引用次数: 0

Abstract

We report an unusual case of anaphylaxis induced by the lysozyme-containing over-the-counter-drug Lysopaine®, which contains 20 mg lysozyme hydrochloride and 1.5 mg cetylpyridinium chloride, in a 9-year-old child with allergy to hen's egg as well as multiple IgE-mediated food allergies. The involvement of lysozyme was confirmed by positive skin prick tests for Lysopaine® and the presence of specific IgE against lysozyme. Our case highlights the importance of properly educating allergic patients to recognize allergens, even minor ones. Despite the presence of lysozyme in various food and drug products, it is not necessarily perceived as an allergenic protein by patients with egg allergy, and the labeling may be misleading, thereby exposing patients to potentially severe reactions.

一例罕见的溶菌酶诱发过敏性休克病例,患儿对鸡蛋过敏。
我们报告了一例由含溶菌酶的非处方药 Lysopaine® 引发的过敏性休克的不寻常病例,该药物含有 20 毫克盐酸溶菌酶和 1.5 毫克氯化乙酰吡啶,患儿 9 岁,对母鸡蛋过敏,并伴有多种 IgE 介导的食物过敏。溶菌酶的参与是通过对 Lysopaine® 的阳性皮肤点刺试验和针对溶菌酶的特异性 IgE 的存在得到证实的。我们的病例强调了正确教育过敏患者识别过敏原(即使是小过敏原)的重要性。尽管溶菌酶存在于各种食品和药品中,但鸡蛋过敏患者并不一定将其视为过敏原蛋白,标签可能会误导患者,从而使患者面临潜在的严重反应。
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来源期刊
Archives De Pediatrie
Archives De Pediatrie 医学-小儿科
CiteScore
2.80
自引率
5.60%
发文量
106
审稿时长
24.1 weeks
期刊介绍: Archives de Pédiatrie publishes in English original Research papers, Review articles, Short communications, Practice guidelines, Editorials and Letters in all fields relevant to pediatrics. Eight issues of Archives de Pédiatrie are released annually, as well as supplementary and special editions to complete these regular issues. All manuscripts submitted to the journal are subjected to peer review by international experts, and must: Be written in excellent English, clear and easy to understand, precise and concise; Bring new, interesting, valid information - and improve clinical care or guide future research; Be solely the work of the author(s) stated; Not have been previously published elsewhere and not be under consideration by another journal; Be in accordance with the journal''s Guide for Authors'' instructions: manuscripts that fail to comply with these rules may be returned to the authors without being reviewed. Under no circumstances does the journal guarantee publication before the editorial board makes its final decision. Archives de Pédiatrie is the official publication of the French Society of Pediatrics.
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