N-(2-Aminobenzoyl)benzotriazole Mediated Synthesis of 3-Acyl-2-alkyl(aryl)-4-hydroxyquinolines and 3-Acylamino-4(3H) quinazolinones.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-10-16 eCollection Date: 2024-01-01 DOI:10.55730/1300-0527.3642

İlbilge Merve Şenol, Sevtem Gökbulut Satioğlu, İlhami Çelik

引用次数: 0

Abstract

New methods have been developed for the synthesis of the substituted quinolines and quinazolinones derivatives by utilizing N-(2-aminobenzoyl)benzotriazoles under mild reaction conditions. 3-Acyl-2-alkyl(aryl)-4-hydroxyquinolines were obtained in modarete yields by the reaction of N-(2-aminobenzoyl)benzotriazoles and diketones in the presence of tert-BuOK. 3-Acylamino-4(3H) quinazolinones were obtained in good yields via N-(2-aminobenzoyl)benzotriazoles, orthoester and hyrazides in one-pot.

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N-(2-氨基苯甲酰基)苯并三唑介导的 3-酰基-2-烷基(芳基)-4-羟基喹啉和 3-酰氨基-4(3H)喹唑啉酮的合成。

利用 N-(2-氨基苯甲酰基)苯并三唑在温和的反应条件下合成取代的喹啉和喹唑啉酮衍生物的新方法已经开发出来。在叔丁氧钾存在下，N-(2-氨基苯甲酰基)苯并三唑和二酮反应得到 3-酰基-2-烷基(芳基)-4-羟基喹啉，产率为模数。通过 N-(2-氨基苯甲酰基)苯并三唑、正酯和酰肼，以一锅法获得了 3-酰氨基-4(3H)喹唑啉酮，收率很高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.