KRAS degradation averts PDAC chemoresistance

IF 23.5 1区医学 Q1 ONCOLOGY

Nature cancer Pub Date : 2024-03-27 DOI:10.1038/s43018-023-00708-7

Laura Leonhardt, Matthias Hebrok

引用次数: 0

Abstract

Effectively targeting deregulated KRAS signaling remains an unmet clinical need, as current approaches commonly lead to the development of chemoresistance in clinical settings. ADAM9-mediated lysosomal KRAS degradation is now shown to counteract PDAC chemoresistance independently of mutational status.

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降解 KRAS 可避免 PDAC 的化疗耐药性

有效靶向失调的 KRAS 信号转导仍是一项尚未满足的临床需求，因为目前的方法通常会导致临床化疗耐药性的产生。现在，ADAM9 介导的溶酶体 KRAS 降解已被证明可以抵消 PDAC 的化疗耐药性，而与突变状态无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature cancer Medicine-Oncology

CiteScore

31.10

自引率

1.80%

发文量

129

期刊介绍： Cancer is a devastating disease responsible for millions of deaths worldwide. However, many of these deaths could be prevented with improved prevention and treatment strategies. To achieve this, it is crucial to focus on accurate diagnosis, effective treatment methods, and understanding the socioeconomic factors that influence cancer rates. Nature Cancer aims to serve as a unique platform for sharing the latest advancements in cancer research across various scientific fields, encompassing life sciences, physical sciences, applied sciences, and social sciences. The journal is particularly interested in fundamental research that enhances our understanding of tumor development and progression, as well as research that translates this knowledge into clinical applications through innovative diagnostic and therapeutic approaches. Additionally, Nature Cancer welcomes clinical studies that inform cancer diagnosis, treatment, and prevention, along with contributions exploring the societal impact of cancer on a global scale. In addition to publishing original research, Nature Cancer will feature Comments, Reviews, News & Views, Features, and Correspondence that hold significant value for the diverse field of cancer research.

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