Nivolumab as a Promising Treatment Option for Metastatic Salivary Duct Carcinoma.

IF 3.2 4区 医学 Q3 IMMUNOLOGY
Journal of Immunotherapy Pub Date : 2024-09-01 Epub Date: 2024-03-28 DOI:10.1097/CJI.0000000000000513
Luis Bugia, Frederic Jungbauer, Lena Zaubitzer, Christian Hörner, Kirsten Merx, Abo-Madyan Yasser, Thomas Germann, Anne Lammert, Claudia Scherl, Nicole Rotter, Annette Affolter
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引用次数: 0

Abstract

Salivary duct carcinomas (SDC) of the parotid gland are rarely occurring highly malignant tumors. A 65-year-old man presented with a preauricular mass. After surgical treatment and histologic examination, the findings were interpreted as a squamous cell carcinoma (SCC) metastasis of the parotid gland deriving from a cancer of unknown primary DD primary SCC of the parotid gland. Adjuvant platinum-based radiochemotherapy was administered in domo. However, re-staging revealed multiple size-progressive pulmonary round lesions. After resection and histological examination of a pulmonary mass and in synopsis with the primary tumor, the initial diagnosis of SCC was revised to SDC of the parotid gland. With positive HER-2 status, off-label trastuzumab/docetaxel was initiated in an individual healing attempt, during which the pulmonary metastases showed clear progression. Consequently, the patient received immunotherapy with nivolumab according to his negative PD-L1 status. After 57 cycles of nivolumab, the patient presents with partial remission and in good condition. We report, for the first time, a robust response of metastatic SDC to checkpoint inhibition with nivolumab without additional radiotherapy.

Nivolumab是治疗转移性唾液腺导管癌的一种很有前途的方法。
腮腺唾液腺导管癌(SDC)是一种罕见的高度恶性肿瘤。一名 65 岁的男子出现耳前肿块。经过手术治疗和组织学检查,结果被解释为腮腺鳞状细胞癌(SCC)转移瘤,来源于原发性不明的腮腺原发性 SCC。患者接受了以铂为基础的辅助放化疗。然而,重新分期后发现了多个大小呈进行性发展的肺圆形病灶。在对肺部肿块进行切除和组织学检查并与原发肿瘤进行对比后,最初的 SCC 诊断被修改为腮腺 SDC。由于患者的 HER-2 状态为阳性,在一次个体治疗尝试中,患者接受了标签外曲妥珠单抗/多西他赛治疗,在此期间,肺转移灶出现了明显的进展。因此,患者根据其 PD-L1 阴性状态接受了 nivolumab 免疫疗法。经过 57 个周期的尼夫单抗治疗后,患者病情得到部分缓解,目前状况良好。我们首次报道了转移性 SDC 对使用 nivolumab 的检查点抑制剂的强效反应,而无需额外的放疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Immunotherapy
Journal of Immunotherapy 医学-免疫学
CiteScore
6.90
自引率
0.00%
发文量
79
审稿时长
6-12 weeks
期刊介绍: Journal of Immunotherapy features rapid publication of articles on immunomodulators, lymphokines, antibodies, cells, and cell products in cancer biology and therapy. Laboratory and preclinical studies, as well as investigative clinical reports, are presented. The journal emphasizes basic mechanisms and methods for the rapid transfer of technology from the laboratory to the clinic. JIT contains full-length articles, review articles, and short communications.
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