Triglyceride-glucose index predicts major adverse cardiovascular events in patients with chronic kidney disease.

IF 1.8 4区医学 Q3 UROLOGY & NEPHROLOGY

International Urology and Nephrology Pub Date : 2024-08-01 Epub Date: 2024-03-27 DOI:10.1007/s11255-024-04005-9

Kangbo Li, Qiqi Hou, Xinyi Li, Liying Tian, Liyan Wang, Shouling Wu, Quanle Han

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Abstract

Background and purpose: Triglyceride-glucose (TyG) index has been regarded as a reliable surrogate marker of insulin resistance for predicting cardiovascular outcomes. The current study aimed to explore the associations between TyG index with major adverse cardiovascular events (MACE) in patients with chronic kidney disease (CKD).

Methods/patients: 13,517 patients with chronic kidney disease (CKD) from the Kailuan study were included. Patients were divided into quartiles according to the TyG index. The outcomes were MACE, including acute myocardial infarction (AMI) and ischemic stroke (IS). The association between TyG index and the risk of MACE was analyzed by Cox regression models.

Results: During 13.87-year follow-up, a total 1356 MACEs occurred. Multivariable Cox proportional-hazards analyses showed that a higher TyG index quartile was associated with an elevated risk of MACE.

Conclusions: TyG index is significantly related to MACE in patients with CKD. TyG index can be regarded as a novel predictor of MACE for patients with CKD.

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甘油三酯-葡萄糖指数可预测慢性肾病患者的主要心血管不良事件。

背景和目的：甘油三酯-葡萄糖（TyG）指数被认为是预测心血管预后的胰岛素抵抗的可靠替代指标。本研究旨在探讨TyG指数与慢性肾脏病（CKD）患者主要不良心血管事件（MACE）之间的关系：纳入开滦研究的13517名慢性肾脏病（CKD）患者。根据 TyG 指数将患者分为四等分。研究结果为MACE，包括急性心肌梗死（AMI）和缺血性卒中（IS）。通过Cox回归模型分析了TyG指数与MACE风险之间的关系：结果：在13.87年的随访期间，共发生了1356例MACE。多变量考克斯比例危险分析显示，TyG指数四分位数越高，MACE风险越高：结论：TyG指数与慢性肾脏病患者的MACE密切相关。结论：TyG指数与慢性肾脏病患者的MACE密切相关，TyG指数可被视为慢性肾脏病患者MACE的新型预测指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Urology and Nephrology 医学-泌尿学与肾脏学

CiteScore

3.40

自引率

5.00%

发文量

329

审稿时长

1.7 months

期刊介绍： International Urology and Nephrology publishes original papers on a broad range of topics in urology, nephrology and andrology. The journal integrates papers originating from clinical practice.