Antidiabetic Evaluation of Kigelia pinnata Root Bark Extract in Streptozotocin-Induced Type-2 Diabetes Model of Rats.

IF 1.6 4区 医学 Q4 BIOCHEMICAL RESEARCH METHODS
Assay and drug development technologies Pub Date : 2024-05-01 Epub Date: 2024-03-28 DOI:10.1089/adt.2023.104
Ravindra Kumar, Neeraj Kumar, Satyendra Kumar Rajput, Sudhanshu Mallan, Arun Kumar, Balwant Singh Rawat, Naresh Kumar Rangra, Shamsher Singh
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引用次数: 0

Abstract

Diabetes mellitus (DM) is the most common endocrine disorder characterized by increased blood glucose levels resulting from defective insulin secretion, resistance to insulin action, or both. DM is often associated with severe complications, and there is an increasing appreciation that cognitive function declines in DM. The aim of this research work was to evaluate Kigelia pinnata root bark extract in Streptozotocin (STZ)-induced type-2 diabetes. Experimental diabetes was induced by a single administration of STZ (60 mg/kg, intraperitoneal [i.p.]), immediately after the STZ administration, and all animals were fed with normal food and water. Nicotinamide was administered (120 mg/kg, i.p.) 15 min before STZ. The development of hyperglycemia was confirmed by the elevated blood glucose levels determined at fixed intervals, which was confirmed by measuring fasting blood glucose levels in rats' blood taken from the tail vein. Supplementation with ethanolic extract of K. pinnata root bark (EEKP) significantly reduced the elevated blood glucose in STZ-induced hyperglycemia in rats. EEKP significantly restored the biochemical and antioxidant defense system. On the final day of the protocol, the extract also reduced inflammatory cytokines in the blood serum.

松萝根皮提取物在链脲佐菌素诱导的 2 型糖尿病模型大鼠中的抗糖尿病评价
糖尿病(DM)是最常见的内分泌疾病,其特点是由于胰岛素分泌缺陷、胰岛素作用抵抗或两者兼而有之而导致血糖水平升高。糖尿病通常伴有严重的并发症,而且人们越来越认识到,糖尿病患者的认知功能会下降。这项研究的目的是评估松萝根皮提取物对链脲佐菌素(STZ)诱导的 2 型糖尿病的作用。实验性糖尿病是通过单次给予 STZ(60 毫克/千克,腹腔注射 [i.p.])诱发的。在 STZ 给药前 15 分钟给动物注射烟酰胺(120 毫克/千克,静脉注射)。在固定时间间隔内测定的血糖水平升高证实了高血糖的发生,通过测量大鼠尾静脉血中的空腹血糖水平也证实了这一点。补充羽扇豆根皮乙醇提取物(EEKP)可显著降低 STZ 诱导的高血糖大鼠的血糖升高。EEKP 能明显恢复大鼠的生化和抗氧化防御系统。在方案的最后一天,提取物还能降低血清中的炎症细胞因子。
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来源期刊
Assay and drug development technologies
Assay and drug development technologies 医学-生化研究方法
CiteScore
3.60
自引率
0.00%
发文量
33
审稿时长
>12 weeks
期刊介绍: ASSAY and Drug Development Technologies provides access to novel techniques and robust tools that enable critical advances in early-stage screening. This research published in the Journal leads to important therapeutics and platforms for drug discovery and development. This reputable peer-reviewed journal features original papers application-oriented technology reviews, topical issues on novel and burgeoning areas of research, and reports in methodology and technology application. ASSAY and Drug Development Technologies coverage includes: -Assay design, target development, and high-throughput technologies- Hit to Lead optimization and medicinal chemistry through preclinical candidate selection- Lab automation, sample management, bioinformatics, data mining, virtual screening, and data analysis- Approaches to assays configured for gene families, inherited, and infectious diseases- Assays and strategies for adapting model organisms to drug discovery- The use of stem cells as models of disease- Translation of phenotypic outputs to target identification- Exploration and mechanistic studies of the technical basis for assay and screening artifacts
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