Two Phylogenetic Cohorts of the Nucleocapsid Protein NP and Their Correlation with the Host Range of Influenza A Viruses

IF 0.8 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Doklady Biochemistry and Biophysics Pub Date : 2024-03-27 DOI:10.1134/S1607672924700789

A. I. Chernyshova, O. P. Zhirnov

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Abstract

Influenza A virus has a wide natural areal among birds, mammals, and humans. One of the main regulatory adaptors of the virus host range is the major NP protein of the viral nucleocapsid. Phylogenetic analysis of the NP protein of different viruses has revealed the existence of two phylogenetic cohorts in human influenza virus population. Cohort I includes classical human viruses that caused epidemics in 1957, 1968, 1977. Cohort II includes the H1N1/2009pdm virus, which had a mixed avian–swine origin but caused global human pandemic. Also, the highly virulent H5N1 avian influenza virus emerged in 2021 and caused outbreaks of lethal infections in mammals including humans, appeared to have the NP gene of the second phylogenetic cohort and, therefore, by the type of adaptation to human is similar to the H1N1/2009pdm virus and seems to possess a high epidemic potential for humans. The data obtained shed light on pathways and dynamics of adaptation of avian influenza viruses to humans and propose phylogenetic algorithm for systemic monitoring of dangerous virus strains to predict epidemic harbingers and take immediate preventive measures.

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核苷酸蛋白 NP 的两个系统发育群及其与甲型流感病毒宿主范围的相关性。

甲型流感病毒在鸟类、哺乳动物和人类中的自然分布范围很广。病毒宿主范围的主要调控适应因子之一是病毒核壳的主要 NP 蛋白。对不同病毒的 NP 蛋白进行的系统发育分析表明，在人类流感病毒群体中存在两个系统发育群。组群 I 包括在 1957 年、1968 年和 1977 年引起流行的经典人类病毒。组群 II 包括 H1N1/2009pdm 病毒，该病毒源于禽流感和猪流感混合感染，但引起了全球人类流感大流行。此外，2021 年出现的高致病性 H5N1 禽流感病毒在包括人类在内的哺乳动物中爆发致命性感染，该病毒似乎具有第二个系统发育群的 NP 基因，因此，从对人类的适应类型来看，它与 H1N1/2009pdm 病毒相似，似乎对人类具有很高的流行潜力。所获得的数据揭示了禽流感病毒对人类适应的途径和动态，并提出了系统监测危险病毒株的系统发生学算法，以预测流行病的先兆并立即采取预防措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Doklady Biochemistry and Biophysics 生物-生化与分子生物学

CiteScore

1.60

自引率

12.50%

发文量

审稿时长

6-12 weeks

期刊介绍： Doklady Biochemistry and Biophysics is a journal consisting of English translations of articles published in Russian in biochemistry and biophysics sections of the Russian-language journal Doklady Akademii Nauk. The journal''s goal is to publish the most significant new research in biochemistry and biophysics carried out in Russia today or in collaboration with Russian authors. The journal accepts only articles in the Russian language that are submitted or recommended by acting Russian or foreign members of the Russian Academy of Sciences. The journal does not accept direct submissions in English.