Effect of Glycerol Content in Gelatin/Glycerol Composite Films Loaded with Erythromycin

IF 1 4区化学 Q4 POLYMER SCIENCE

Polymer Science, Series A Pub Date : 2024-03-25 DOI:10.1134/S0965545X23600357

Mitra Baghali, Hakimeh Ziyadi, Seeram Ramakrishna, Anna Chernova, Antonio Di Martino

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Abstract

Due to wide application of biomaterials in drug delivery systems for wound healing, this research work is focused on the development and characterization of a Gelatin/Glycerol composite film for delivering the antibiotic Erythromycin. The aim was preparing gelatin/glycerol films loaded with erythromycin suitable for a future application as a patch for skin wound healing application. A set of films were prepared with various gelatin to glycerol weight ratio and the impact of glycerol content on the mechanical, physicochemical and thermal behavior of film evaluated. Erythromycin was loaded into the film and the antibacterial activity evaluated versus E.coli and S.aureus. Results demonstrate a correlation between the content of glycerol and the physico-chemical properties of the film. The Ge/GY films containing the drug show good antibacterial effects only against Staphylococcus aureus bacteria. TGA and DSC of Ge/ GY thin films showed thermal stability until 110°C, however, the complete decomposition occurred at 350°C.

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载入红霉素的明胶/甘油复合薄膜中甘油含量的影响

摘要由于生物材料在伤口愈合给药系统中的广泛应用，本研究工作的重点是开发和表征一种用于给药抗生素红霉素的明胶/甘油复合薄膜。目的是制备出负载红霉素的明胶/甘油薄膜，以备将来用作皮肤伤口愈合贴片。研究人员采用不同的明胶与甘油重量比制备了一组薄膜，并评估了甘油含量对薄膜机械、理化和热性能的影响。在薄膜中加入红霉素，并评估其对大肠杆菌和金黄色葡萄球菌的抗菌活性。结果表明，甘油含量与薄膜的物理化学特性之间存在相关性。含有药物的 Ge/GY 薄膜仅对金黄色葡萄球菌具有良好的抗菌效果。Ge/GY 薄膜的 TGA 和 DSC 显示其在 110°C 前具有热稳定性，但在 350°C 时发生完全分解。

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来源期刊

Polymer Science, Series A 化学-高分子科学

CiteScore

1.70

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： Polymer Science, Series A is a journal published in collaboration with the Russian Academy of Sciences. Series A includes experimental and theoretical papers and reviews devoted to physicochemical studies of the structure and properties of polymers (6 issues a year). All journal series present original papers and reviews covering all fundamental aspects of macromolecular science. Contributions should be of marked novelty and interest for a broad readership. Articles may be written in English or Russian regardless of country and nationality of authors. All manuscripts are peer reviewed. Online submission via Internet to the Series A, B, and C is available at http://polymsci.ru.