Feasibility study on the separation and purification of sinomenine hydrochloride from Caulis sinomenii solution based on membrane ultrafiltration technology
Xi Wang , Xiaoyang Zhang , Guoming Zhou , Jiahe Qian , Zheng Li , Wenlong Li
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引用次数: 0
Abstract
The traditional preparation of sinomenine hydrochloride (SH) requires more chloroform and the steps are cumbersome. The use of membrane separation technology can solve the above problems. In this study, Box-Behnken design (BBD) was used to optimize the membrane separation and purification process of SH based on single factor experiments of feed temperatures, diafiltration washing volume, and molecular weight cut-off (MWCO) ranges, the optimized evaluation index is the permeability of SH through the membrane. In addition, to evaluate the effectiveness of membrane separation, the recovery rate of chloroform and the purity of crude SH were compared between traditional separation and purification methods and membrane separation techniques. Finally, the precipitate after extraction was recovered. The optimal process conditions determined are feed temperature of 46 °C, diafiltration washing volume of 75%, and MWCO range of 1 kDa to 150Da. Compared with traditional methods, the implementation of membrane separation can increase the recovery rate of chloroform by 10%. The application of membrane separation technology not only makes the extraction solution clearer, but also reduces the demand for organic solvents during the extraction process. Therefore, this method represents a green and environmentally friendly separation and purification method.
期刊介绍:
Sustainable Chemistry and Pharmacy publishes research that is related to chemistry, pharmacy and sustainability science in a forward oriented manner. It provides a unique forum for the publication of innovative research on the intersection and overlap of chemistry and pharmacy on the one hand and sustainability on the other hand. This includes contributions related to increasing sustainability of chemistry and pharmaceutical science and industries itself as well as their products in relation to the contribution of these to sustainability itself. As an interdisciplinary and transdisciplinary journal it addresses all sustainability related issues along the life cycle of chemical and pharmaceutical products form resource related topics until the end of life of products. This includes not only natural science based approaches and issues but also from humanities, social science and economics as far as they are dealing with sustainability related to chemistry and pharmacy. Sustainable Chemistry and Pharmacy aims at bridging between disciplines as well as developing and developed countries.