B-ultrasound or CT-guided 3D-printing individualized non-coplanar template brachytherapy for the treatment of locally uncontrolled recurrent head and neck squamous cell carcinoma.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-02-01 Epub Date: 2024-02-28 DOI:10.5114/ada.2024.136252

Pengbing Han, Fengju Li, Yanping Zhang, Liying Gao, Guiqiong Zhang, Qing Guo, Yuxia Zhu, Qun Su

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引用次数: 0

Abstract

Introduction: It is worth to explore a more effective treatment method to minimize the damage for patients during the treatment process.

Aim: To explore the method, feasibility and efficacy of B-ultrasound or computed tomography (CT)-guided 3D printing individualized non-coplanar template brachytherapy in the treatment of locally uncontrolled recurrent head and neck squamous cell carcinoma.

Material and methods: Ten patients with locally uncontrolled recurrent head and neck squamous cell carcinoma who were treated in our department from August 2021 to February 2023 were collected and treated by 3D printing individualized non-coplanar template brachytherapy under the guidance of B-ultrasound or CT, using the 192Ir high-dose rate afterloading treatment machine of NUCLETRON Technologies GmbH. The radiation source was 192Ir, with a diameter of 0.5 mm, a length of 3.5 mm, a total dose of 10-24 Gy, 5-8 Gy/time, once a week.

Results: According to the efficacy evaluation criteria, CT scan was performed after 1-6 months, followed up for 24 months, including CR 40% (4/10), PR 50% (5/10), NC 10% (5/10), PD 0 (0). The total effective rate of CR + PR was 90% (9/10), the 6-month local control rate was 90%, the 12-month local control rate was 80%, the 18-month local control rate was 70%, and the 24-month local control rate was 70%. The overall survival rate at 24 months was 100%.

Conclusions: Safe and effective interpolation is used to guide the 3D printing of a single non-coplanar template with B-ultrasound or CT in the radiotherapy of local and uncontrolled recurrent head and neck squamous cell carcinoma. According to the guidance of B-ultrasound or CT, the 3D printing individualized non-coplanar template has an obvious healing effect especially in the brachytherapy, and can also protect the functional organs well, with less side effects and fewer complications. Therefore, this method is the most effective for the treatment of locally uncontrolled recurrent head and neck squamous cell carcinoma.

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B超或CT引导下的三维打印个体化非共面模板近距离放射治疗局部未控制的复发性头颈部鳞状细胞癌。

导言目的：探讨B超或CT引导下3D打印个体化非共面模板近距离治疗局部未控制复发性头颈部鳞癌的方法、可行性及疗效：收集2021年8月至2023年2月在我科接受治疗的10例局部未控制的复发性头颈部鳞癌患者，在B超或CT引导下，使用德国NUCLETRON Technologies GmbH公司的192Ir高剂量率后装治疗机进行3D打印个体化非共面模板近距离放射治疗。放射源为 192Ir，直径 0.5 毫米，长度 3.5 毫米，总剂量 10-24 Gy，5-8 Gy/次，每周一次：根据疗效评价标准，1-6个月后进行CT扫描，随访24个月，其中CR 40%（4/10），PR 50%（5/10），NC 10%（5/10），PD 0（0）。CR+PR总有效率为90%（9/10），6个月局部控制率为90%，12个月局部控制率为80%，18个月局部控制率为70%，24个月局部控制率为70%。24个月的总生存率为100%：在局部和未控制的复发性头颈部鳞状细胞癌的放疗中，利用B超或CT引导单个非平面模板的三维打印是安全有效的插值方法。在B超或CT的引导下，3D打印个体化非平面模板具有明显的疗效，特别是在近距离放疗中，还能很好地保护功能器官，副作用小，并发症少。因此，这种方法对于治疗局部未控制的复发性头颈部鳞状细胞癌最为有效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.