Aryl hydrocarbon receptor role in chronic inflammatory skin diseases: a narrative review.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-02-01 Epub Date: 2024-02-28 DOI:10.5114/ada.2023.135617

Michał Dec, Hubert Arasiewicz

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引用次数: 0

Abstract

The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that has gained increasing attention in the field of dermatology due to its multifaceted role in skin health and disease. This review provides a comprehensive overview of the current state of knowledge regarding the AHR and its implications in dermatological conditions. The AHR is well known for its involvement in xenobiotic metabolism, particularly in response to polycyclic aromatic hydrocarbons and dioxins. However, recent research has unveiled its pivotal role in the skin immune response, barrier function, and homeostasis. The AHR signalling pathway is intricately linked to various dermatological disorders, including psoriasis, atopic dermatitis, acne and hidradenitis suppurativa. In this review, we delve into the molecular mechanisms through which AHR activation influences skin physiology and highlight how dysregulation can lead to pathological conditions. Moreover, we discuss the emerging therapeutic potential of AHR modulators in the treatment of skin diseases. In conclusion, the AHR is a pivotal player in dermatology, with a multifaceted role in skin physiology and pathology. Understanding the intricacies of AHR signalling in the skin offers promising avenues for the development of novel therapies and preventive strategies for various dermatological conditions. Further research is warranted to elucidate the full scope of AHR's contributions to dermatology and its potential as a therapeutic target.

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芳基烃受体在慢性炎症性皮肤病中的作用：综述。

芳基烃受体（AHR）是一种配体激活的转录因子，由于其在皮肤健康和疾病中的多方面作用，它在皮肤病学领域日益受到关注。本综述全面概述了有关 AHR 及其对皮肤病影响的现有知识。众所周知，AHR 参与异生物代谢，尤其是对多环芳烃和二恶英的反应。然而，最近的研究揭示了它在皮肤免疫反应、屏障功能和稳态中的关键作用。AHR 信号通路与牛皮癣、特应性皮炎、痤疮和化脓性扁桃体炎等各种皮肤病有着错综复杂的联系。在这篇综述中，我们将深入探讨 AHR 激活影响皮肤生理的分子机制，并重点介绍调节失调如何导致病理状况。此外，我们还讨论了 AHR 调节剂在治疗皮肤病方面的新兴治疗潜力。总之，AHR 在皮肤病学中起着举足轻重的作用，在皮肤生理和病理中起着多方面的作用。了解皮肤中 AHR 信号的复杂性为开发新型疗法和各种皮肤病的预防策略提供了广阔的前景。要全面阐明 AHR 对皮肤病学的贡献及其作为治疗靶点的潜力，还需要进一步的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.