Probiotics supplementation in the treatment of male infertility: A Systematic Review.

IF 1.8 Q3 OBSTETRICS & GYNECOLOGY
Licia Cristina Silva de Lima Oliveira, Elton Carvalho Costa, Fernanda Domingues Gomes Martins, Alcenir Sales da Rocha, Girlandia Alexandre Brasil
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引用次数: 0

Abstract

Infertility is a widespread global issue that affects approximately 15% of sexually active and active couples, which contributes to about 50% of cases. Currently, the condition remains prevalent and often inadequately treated. This systematic review aims to evaluate existing studies investigating the effects of probiotic supplementation in men. A comprehensive search was conducted across major databases, including PubMed, Cochrane, Science Direct, and Scielo, using relevant keywords such as 'probiotic' OR 'Lactobacillus' OR 'Bifidobacterium' AND 'Male infertility' OR 'male fertility' OR 'sperm quality' OR 'sperm motility' OR 'oligoasthenoteratozoospermia' and their Portuguese equivalents. Four randomized clinical studies met the inclusion criteria, focusing on men diagnosed with idiopathic male infertility (oligozoospermia, teratozoospermia, and asthenozoospermia). The findings revealed that probiotic administration exhibited promising antioxidant properties by combating reactive oxygen species (ROS), consequently protecting sperm DNA from damage that correlates with declining sperm quality. Significant improvements were observed across all sperm parameters, with notable enhancement in motility. Consequently, probiotic supplementation emerges as a potential therapeutic alternative for men diagnosed with idiopathic infertility, demonstrating positive effects on sperm quality.

补充益生菌治疗男性不育症:系统综述。
不孕不育是一个普遍的全球性问题,影响着约 15%的性活跃夫妇,占不孕不育病例的 50%。目前,不孕不育症仍然很普遍,而且往往得不到适当的治疗。本系统性综述旨在评估现有的有关男性补充益生菌效果的研究。我们使用 "益生菌 "或 "乳酸杆菌 "或 "双歧杆菌 "和 "男性不育 "或 "男性生育力 "或 "精子质量 "或 "精子活力 "或 "少精症 "等相关关键词及其葡萄牙语对应词,在PubMed、Cochrane、Science Direct和Scielo等主要数据库中进行了全面检索。四项随机临床研究符合纳入标准,主要针对被诊断为特发性男性不育(少精子症、畸形精子症和无精子症)的男性。研究结果表明,服用益生菌可对抗活性氧(ROS),从而保护精子 DNA 免受损伤,而损伤与精子质量下降有关,因此益生菌具有良好的抗氧化特性。所有精子参数都有明显改善,精子活力显著增强。因此,对于被诊断为特发性不育症的男性来说,补充益生菌是一种潜在的替代疗法,对精子质量有积极影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.30
自引率
6.70%
发文量
56
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