Differences in Plasma Fatty Acid Composition Related to Chronic Pancreatitis: A Pilot Study.

IF 1.7 4区 医学 Q3 GASTROENTEROLOGY & HEPATOLOGY
Pancreas Pub Date : 2024-05-01 Epub Date: 2024-03-13 DOI:10.1097/MPA.0000000000002318
Kristyn Gumpper-Fedus, Olivia Crowe, Phil A Hart, Valentina Pita-Grisanti, Ericka Velez-Bonet, Martha A Belury, Mitchell L Ramsey, Rachel M Cole, Niharika Badi, Stacey Culp, Alice Hinton, Luis F Lara, Somashekar G Krishna, Darwin L Conwell, Zobeida Cruz-Monserrate
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引用次数: 0

Abstract

Objectives: Chronic pancreatitis (CP) is an inflammatory disease affecting the absorption of fat-soluble nutrients. Signaling in pancreatic cells that lead to inflammation may be influenced by fatty acids (FAs) through diet and de novo lipogenesis. Here, we investigated the relationship between plasma FA composition in CP with heterogeneity of etiology and complications of CP.

Materials and methods: Blood and clinical parameters were collected from subjects with CP (n = 47) and controls (n = 22). Plasma was analyzed for FA composition using gas chromatography and compared between controls and CP and within CP.

Results: Palmitic acid increased, and linoleic acid decreased in CP compared with controls. Correlations between age or body mass index and FAs are altered in CP compared with controls. Diabetes, pancreatic calcifications, and substance usage, but not exocrine pancreatic dysfunction, were associated with differences in oleic acid and linoleic acid relative abundance in CP. De novo lipogenesis index was increased in the plasma of subjects with CP compared with controls and in calcific CP compared with noncalcific CP.

Conclusions: Fatty acids that are markers of de novo lipogenesis and linoleic acid are dysregulated in CP depending on the etiology or complication. These results enhance our understanding of CP and highlight potential pathways targeting FAs for treating CP.

与慢性胰腺炎有关的血浆脂肪酸组成差异:一项试点研究
目的:慢性胰腺炎(CP)是一种影响脂溶性营养物质吸收的炎症性疾病:慢性胰腺炎(CP)是一种影响脂溶性营养物质吸收的炎症性疾病。胰腺细胞中导致炎症的信号传递可能会受到脂肪酸(FA)通过饮食和新脂肪生成的影响。在此,我们研究了胰腺癌血浆脂肪酸组成与胰腺癌病因和并发症异质性之间的关系:收集了 CP 患者(47 人)和对照组(22 人)的血液和临床参数。采用气相色谱法分析血浆中的脂肪酸组成,并在对照组和 CP 之间以及 CP 内部进行比较:结果:与对照组相比,CP 中棕榈酸增加,亚油酸减少。与对照组相比,CP 中年龄或体重指数与 FA 之间的相关性发生了变化。糖尿病、胰腺钙化和药物使用(而非胰腺外分泌功能障碍)与氯化石蜡中油酸和亚油酸相对丰度的差异有关。与对照组相比,CP 患者血浆中新生脂肪生成指数增加;与非钙化 CP 相比,钙化 CP 患者血浆中新生脂肪生成指数增加:结论:作为新脂肪生成标志的脂肪酸和亚油酸在 CP 中因病因或并发症的不同而失调。这些结果加深了我们对 CP 的了解,并强调了以脂肪酸为靶点治疗 CP 的潜在途径。
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来源期刊
Pancreas
Pancreas 医学-胃肠肝病学
CiteScore
4.70
自引率
3.40%
发文量
289
审稿时长
1 months
期刊介绍: Pancreas provides a central forum for communication of original works involving both basic and clinical research on the exocrine and endocrine pancreas and their interrelationships and consequences in disease states. This multidisciplinary, international journal covers the whole spectrum of basic sciences, etiology, prevention, pathophysiology, diagnosis, and surgical and medical management of pancreatic diseases, including cancer.
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