Widefield, Swept-Source Optical Coherence Tomography Angiography Metrics as Predictors of Anti-VEGF Treatment in Retinal Vein Occlusions.

IF 0.9 4区医学 Q4 OPHTHALMOLOGY

Ophthalmic surgery, lasers & imaging retina Pub Date : 2024-07-01 Epub Date: 2024-03-01 DOI:10.3928/23258160-20240208-02

Matthew J Finn, Grace Baldwin, Ines Lains, Itika Garg, Hannah Wescott, Filippos Vingopoulos, Rebecca Zeng, Hanna Choi, Jack Tracy, Peyman Razavi, Diane Sayeh, Nimesh A Patel, David M Wu, Demetrios G Vavvas, John B Miller

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引用次数: 0

Abstract

Background and objective: Our objective was to assess baseline widefield swept-source optical coherence tomography angiography (WF SSOCTA) microvascular metrics as predictors for the number of anti-vascular endothelial growth factor (VEGF) injections and visual acuity (VA) at 12-months follow-up in patients with retinal vein occlusion (RVO).

Patients and methods: This was a prospective study including 49 RVO eyes from 49 patients who had not received an anti-VEGF injection for at least 3 months prior to imaging. Microvascular metrics from 6×6-mm and 12×12-mm angiograms were assessed using linear regression models, adjusting for age.

Results: Reductions in the vessel density (VD) and vessel skeletonized density (VSD) vascular metrics were associated both with a higher number of anti-VEGF injections at all follow-up time points and reduced VA 12 months after imaging in all RVO eyes.

Conclusions: WF SS-OCTA VD and VSD micro-vascular metrics at baseline can prognosticate VA and number of anti-VEGF injections required at 3, 6, and 12 months in RVO eyes. [Ophthalmic Surg Lasers Imaging Retina 2024;55:374-382.].

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宽视场扫源光学相干断层扫描血管造影指标作为视网膜静脉闭塞症抗血管内皮生长因子治疗的预测指标。

背景和目的：我们的目的是评估基线宽场扫源光学相干断层血管成像（WF SSOCTA）微血管指标作为视网膜静脉闭塞（RVO）患者注射抗血管内皮生长因子（VEGF）次数和随访12个月视力（VA）的预测因素：这是一项前瞻性研究，包括 49 名视网膜静脉阻塞患者的 49 只视网膜静脉阻塞眼，这些患者在成像前至少 3 个月未接受过抗血管内皮生长因子注射。使用线性回归模型评估了 6×6 毫米和 12×12 毫米血管造影的微血管指标，并对年龄进行了调整：结果：血管密度（VD）和血管骨架密度（VSD）指标的降低与所有 RVO 眼睛在所有随访时间点抗 VEGF 注射次数的增加和成像后 12 个月视力的降低有关：结论：基线时的WF SS-OCTA VD和VSD微血管指标可预测RVO眼3、6和12个月后的视力和所需的抗血管内皮生长因子注射次数。[眼科手术激光成像视网膜2024;55:xx-xx]。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ophthalmic surgery, lasers & imaging retina OPHTHALMOLOGY-SURGERY

CiteScore

1.80

自引率

0.00%

发文量

期刊介绍： OSLI Retina focuses exclusively on retinal diseases, surgery and pharmacotherapy. OSLI Retina will offer an expedited submission to publication effort of peer-reviewed clinical science and case report articles. The front of the journal offers practical clinical and practice management features and columns specific to retina specialists. In sum, readers will find important peer-reviewed retina articles and the latest findings in techniques and science, as well as informative business and practice management features in one journal.