Retinal Nerve Fiber Layer Changes in Patients With Chronic Obstructive Pulmonary Disease Compared to Healthy Controls: A Meta-analysis.

IF 0.9 4区医学 Q4 OPHTHALMOLOGY

Ophthalmic surgery, lasers & imaging retina Pub Date : 2024-06-01 Epub Date: 2024-03-01 DOI:10.3928/23258160-20240220-01

Dimitrios Kazantzis, Genovefa Machairoudia, Stylianos Kandarakis, George Theodossiadis, Panagiotis Theodossiadis, Irini Chatziralli

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引用次数: 0

Abstract

Background and objective: This study investigated changes in retinal nerve fiber layers (RNFL) in patients diagnosed with chronic obstructive pulmonary disease (COPD) compared to healthy control patients, using optical coherence tomography.

Methods: PubMed, Cochrane Library, and Google Scholar databases were systematically searched for published articles comparing RNFL between patients with COPD and healthy controls. Standardized mean difference (SMD) with 95% confidence interval (CI) was computed to compare continuous variables.

Results: Average RNFL thickness was significantly reduced in COPD patients compared to healthy controls (SMD = -0.31, 95% CI = -0.48 to -0.14, P = 0.0004, I² = 0%). Average RNFL thickness did not differ significantly between patients with mild/moderate COPD and healthy controls (SMD = -0.17, 95% CI = -0.39 to 0.04, P = 0.12, I² = 2%), while a statistically significant reduction in average RNFL thickness was noticed in patients with severe COPD compared to healthy controls (SMD = -0.72, 95% CI = -1.23 to -0.21, P = 0.006, I² = 83%). Average RNFL thickness was significantly higher in patients with mild/moderate COPD compared to patients with severe COPD (SMD = 0.69, 95% CI = 0.29 to 1.09, P = 0.0008, I² = 66%).

Conclusions: This meta-analysis showed that RNFL thickness was decreased in patients with COPD compared to healthy controls. Patients diagnosed with severe COPD seem to be more affected and have thinner RNFL. [Ophthalmic Surg Lasers Imaging Retina 2024;55:334-342.].

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慢性阻塞性肺病患者视网膜神经纤维层的变化与健康对照组的比较：元分析。

背景和目的：本研究采用光学相干断层扫描技术，对慢性阻塞性肺病（COPD）患者视网膜神经纤维层（RNFL）的变化进行了研究：本研究使用光学相干断层扫描技术调查了慢性阻塞性肺病（COPD）患者与健康对照组患者视网膜神经纤维层（RNFL）的变化：在 PubMed、Cochrane Library 和 Google Scholar 数据库中系统搜索了已发表的文章，比较 COPD 患者和健康对照组患者的视网膜神经纤维层（RNFL）。比较连续变量时，计算了标准化平均差（SMD）和95%置信区间（CI）：结果：与健康对照组相比，慢性阻塞性肺病患者的平均 RNFL 厚度明显减少（SMD = -0.31，95% CI = -0.48 至 -0.14，P = 0.0004，I2 = 0%）。轻度/中度慢性阻塞性肺病患者的平均 RNFL 厚度与健康对照组相比无显著差异（SMD = -0.17，95% CI = -0.39 至 0.04，P = 0.12，I2 = 2%），而重度慢性阻塞性肺病患者的平均 RNFL 厚度与健康对照组相比有显著统计学差异（SMD = -0.72，95% CI = -1.23 至 -0.21，P = 0.006，I2 = 83%）。轻度/中度 COPD 患者的平均 RNFL 厚度明显高于重度 COPD 患者（SMD = 0.69，95% CI = 0.29 至 1.09，P = 0.0008，I2 = 66%）：这项荟萃分析表明，与健康对照组相比，慢性阻塞性肺病患者的 RNFL 厚度有所下降。被诊断为严重慢性阻塞性肺病的患者似乎受影响更大，其 RNFL 更薄。[眼科手术激光成像视网膜2024;55:XX-XX]。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ophthalmic surgery, lasers & imaging retina OPHTHALMOLOGY-SURGERY

CiteScore

1.80

自引率

0.00%

发文量

期刊介绍： OSLI Retina focuses exclusively on retinal diseases, surgery and pharmacotherapy. OSLI Retina will offer an expedited submission to publication effort of peer-reviewed clinical science and case report articles. The front of the journal offers practical clinical and practice management features and columns specific to retina specialists. In sum, readers will find important peer-reviewed retina articles and the latest findings in techniques and science, as well as informative business and practice management features in one journal.