High Hepatitis C Cure Rates Among Patients With Alcohol Use at a Safety-Net Hepatitis C Clinic.

IF 4.2 3区 医学 Q1 SUBSTANCE ABUSE
Journal of Addiction Medicine Pub Date : 2024-07-01 Epub Date: 2024-03-26 DOI:10.1097/ADM.0000000000001307
Erica Heiman, Meghan Alexander, Rebecca Zhang, Ziduo Zheng, Lesley S Miller
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引用次数: 0

Abstract

Objectives: We set out to examine several aspects of the relationship between alcohol use and hepatitis C virus (HCV) among a cohort of patients treated at an HCV clinic within a safety net hospital. We examined (1) the prevalence of alcohol use among patients treated for HCV, (2) the likelihood of being started on treatment among patients who reported drinking alcohol compared with those who did not, and (3) the associations between alcohol use and HCV cure.

Methods: We performed a retrospective chart abstraction study using data from the Grady Liver Clinic, a specialty HCV clinic colocated in Grady Memorial Hospital's primary care clinic and run by general internists.

Results: Nine hundred fifty-four patients were included. The sustained virologic response rate among those with 12-week posttreatment measurement was 99.2%, with only 5 patients experiencing virologic failure. None of the alcohol use indicators significantly impacted sustained virologic response or loss to follow-up. Estimates of alcohol use ranged from 28.9% (by International Classification of Diseases, Tenth Revision , code) to 48.9% (clinician documentation). Treatment initiation rates were the same among those who did and did not report alcohol use.

Conclusions: Alcohol use was not associated with decreased HCV cure rates. Our findings validate the inclusion of patients with alcohol use in HCV treatment programs.

在一家安全网丙型肝炎诊所就诊的酗酒患者中,丙型肝炎治愈率较高。
研究目的我们研究了在一家安全网医院的 HCV 诊所接受治疗的一组患者中饮酒与丙型肝炎病毒(HCV)之间关系的几个方面。我们研究了(1)接受 HCV 治疗的患者中饮酒的流行率;(2)与不饮酒的患者相比,饮酒的患者开始接受治疗的可能性;以及(3)饮酒与 HCV 治愈之间的关系:我们利用格雷迪肝病门诊的数据进行了一项回顾性病历摘要研究,格雷迪肝病门诊是设在格雷迪纪念医院初级保健门诊内的一家 HCV 专科门诊,由普通内科医生负责管理:研究共纳入 954 名患者。治疗后 12 周的持续病毒学应答率为 99.2%,仅有 5 名患者出现病毒学失败。酗酒指标均未对持续病毒学应答或随访失败产生重大影响。估计的饮酒率从 28.9%(按国际疾病分类第十版编码)到 48.9%(临床医生记录)不等。在报告和未报告饮酒的人群中,开始治疗的比例相同:酗酒与 HCV 治愈率下降无关。我们的研究结果验证了将酗酒患者纳入 HCV 治疗项目的可行性。
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来源期刊
Journal of Addiction Medicine
Journal of Addiction Medicine 医学-药物滥用
CiteScore
6.10
自引率
9.10%
发文量
260
审稿时长
>12 weeks
期刊介绍: The mission of Journal of Addiction Medicine, the official peer-reviewed journal of the American Society of Addiction Medicine, is to promote excellence in the practice of addiction medicine and in clinical research as well as to support Addiction Medicine as a mainstream medical sub-specialty. Under the guidance of an esteemed Editorial Board, peer-reviewed articles published in the Journal focus on developments in addiction medicine as well as on treatment innovations and ethical, economic, forensic, and social topics including: •addiction and substance use in pregnancy •adolescent addiction and at-risk use •the drug-exposed neonate •pharmacology •all psychoactive substances relevant to addiction, including alcohol, nicotine, caffeine, marijuana, opioids, stimulants and other prescription and illicit substances •diagnosis •neuroimaging techniques •treatment of special populations •treatment, early intervention and prevention of alcohol and drug use disorders •methodological issues in addiction research •pain and addiction, prescription drug use disorder •co-occurring addiction, medical and psychiatric disorders •pathological gambling disorder, sexual and other behavioral addictions •pathophysiology of addiction •behavioral and pharmacological treatments •issues in graduate medical education •recovery •health services delivery •ethical, legal and liability issues in addiction medicine practice •drug testing •self- and mutual-help.
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