Association between HER2 (Ile655Val) polymorphism with risk of breast cancer: An extensive meta-analysis

IF 0.5 Q4 GENETICS & HEREDITY
Sheena Mariam Thomas, B.K. Iyshwarya, Ramakrishnan Veerabathiran
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引用次数: 0

Abstract

Background

Breast cancer (BC), a major global health concern, exhibits molecular heterogeneity influencing treatment decisions. The HER2 gene, particularly the Ile655Val (rs1136201) polymorphism, has been implicated in breast cancer susceptibility, though prior studies present varied findings.

Objective

This meta-analysis explores the correlation between HER2 gene polymorphism and the risk of developing breast cancer.

Methods

A systematic literature exploration was accomplished using PubMed, Embase, and Google Scholar databases. Inclusion criteria encompassed case-control or probable study design, the association of the HER2 gene with breast cancer, and the availability of genotypic data. The Newcastle-Ottawa Scale assessed study quality. Quantitative data analysis employed Review Manager 5.4 and MetaGenyo software, with significance at p < 0.05.

Results

Six studies, encompassing 1964 breast cancer cases and 2511 controls, were incorporated into the analysis. Various genetic models (allele contrast, dominant, over-dominant, recessive) consistently presented a significant correlation linking HER2 polymorphism and breast cancer.

Conclusion

The HER2 gene, vital for cell growth, is implicated in breast cancer. Studies present diverse findings on the association of ethnicity with outcomes. Our meta-analysis supports a significant link, contributing to the understanding of genetic factors in breast cancer. Despite mixed findings in the literature, Our meta-analysis reveals a substantial link between HER2 gene polymorphism and breast cancer. This research adds valuable insights to the existing knowledge, emphasizing the need for continued exploration of HER2 gene polymorphism mechanisms and the importance of diverse population studies. The identified association could have implications for breast cancer risk assessment, early diagnosis, and personalized treatment strategies.

HER2(Ile655Val)多态性与乳腺癌风险之间的关系:广泛的荟萃分析
背景乳腺癌(BC)是全球关注的主要健康问题,其分子异质性影响着治疗决策。HER2 基因,尤其是 Ile655Val (rs1136201) 多态性与乳腺癌易感性有关,但之前的研究结果各不相同。纳入标准包括病例对照或可能的研究设计、HER2 基因与乳腺癌的相关性以及基因型数据的可用性。纽卡斯尔-渥太华量表评估研究质量。定量数据分析采用了 Review Manager 5.4 和 MetaGenyo 软件,显著性为 p < 0.05。各种遗传模型(等位基因对比、显性、过显性、隐性)一致表明,HER2 多态性与乳腺癌之间存在显著相关性。有关种族与结果之间关系的研究结果多种多样。我们的荟萃分析证实了这一重要联系,有助于人们了解乳腺癌的遗传因素。尽管文献研究结果不一,但我们的荟萃分析揭示了 HER2 基因多态性与乳腺癌之间的重要联系。这项研究为现有知识增添了有价值的见解,强调了继续探索 HER2 基因多态性机制的必要性和不同人群研究的重要性。所发现的关联可能会对乳腺癌风险评估、早期诊断和个性化治疗策略产生影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Human Gene
Human Gene Biochemistry, Genetics and Molecular Biology (General), Genetics
CiteScore
1.60
自引率
0.00%
发文量
0
审稿时长
54 days
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