{"title":"Association between HER2 (Ile655Val) polymorphism with risk of breast cancer: An extensive meta-analysis","authors":"Sheena Mariam Thomas, B.K. Iyshwarya, Ramakrishnan Veerabathiran","doi":"10.1016/j.humgen.2024.201280","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Breast cancer (BC), a major global health concern, exhibits molecular heterogeneity influencing treatment decisions. The <em>HER2</em> gene, particularly the Ile655Val (rs1136201) polymorphism, has been implicated in breast cancer susceptibility, though prior studies present varied findings.</p></div><div><h3>Objective</h3><p>This meta-analysis explores the correlation between <em>HER2</em> gene polymorphism and the risk of developing breast cancer.</p></div><div><h3>Methods</h3><p>A systematic literature exploration was accomplished using PubMed, Embase, and Google Scholar databases. Inclusion criteria encompassed case-control or probable study design, the association of the <em>HER2</em> gene with breast cancer, and the availability of genotypic data. The Newcastle-Ottawa Scale assessed study quality. Quantitative data analysis employed Review Manager 5.4 and MetaGenyo software, with significance at <em>p</em> < 0.05.</p></div><div><h3>Results</h3><p>Six studies, encompassing 1964 breast cancer cases and 2511 controls, were incorporated into the analysis. Various genetic models (allele contrast, dominant, over-dominant, recessive) consistently presented a significant correlation linking <em>HER2</em> polymorphism and breast cancer.</p></div><div><h3>Conclusion</h3><p>The <em>HER2</em> gene, vital for cell growth, is implicated in breast cancer. Studies present diverse findings on the association of ethnicity with outcomes. Our meta-analysis supports a significant link, contributing to the understanding of genetic factors in breast cancer. Despite mixed findings in the literature, Our meta-analysis reveals a substantial link between <em>HER2</em> gene polymorphism and breast cancer. This research adds valuable insights to the existing knowledge, emphasizing the need for continued exploration of <em>HER2</em> gene polymorphism mechanisms and the importance of diverse population studies. The identified association could have implications for breast cancer risk assessment, early diagnosis, and personalized treatment strategies.</p></div>","PeriodicalId":29686,"journal":{"name":"Human Gene","volume":"40 ","pages":"Article 201280"},"PeriodicalIF":0.5000,"publicationDate":"2024-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Human Gene","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S277304412400024X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}
引用次数: 0
Abstract
Background
Breast cancer (BC), a major global health concern, exhibits molecular heterogeneity influencing treatment decisions. The HER2 gene, particularly the Ile655Val (rs1136201) polymorphism, has been implicated in breast cancer susceptibility, though prior studies present varied findings.
Objective
This meta-analysis explores the correlation between HER2 gene polymorphism and the risk of developing breast cancer.
Methods
A systematic literature exploration was accomplished using PubMed, Embase, and Google Scholar databases. Inclusion criteria encompassed case-control or probable study design, the association of the HER2 gene with breast cancer, and the availability of genotypic data. The Newcastle-Ottawa Scale assessed study quality. Quantitative data analysis employed Review Manager 5.4 and MetaGenyo software, with significance at p < 0.05.
Results
Six studies, encompassing 1964 breast cancer cases and 2511 controls, were incorporated into the analysis. Various genetic models (allele contrast, dominant, over-dominant, recessive) consistently presented a significant correlation linking HER2 polymorphism and breast cancer.
Conclusion
The HER2 gene, vital for cell growth, is implicated in breast cancer. Studies present diverse findings on the association of ethnicity with outcomes. Our meta-analysis supports a significant link, contributing to the understanding of genetic factors in breast cancer. Despite mixed findings in the literature, Our meta-analysis reveals a substantial link between HER2 gene polymorphism and breast cancer. This research adds valuable insights to the existing knowledge, emphasizing the need for continued exploration of HER2 gene polymorphism mechanisms and the importance of diverse population studies. The identified association could have implications for breast cancer risk assessment, early diagnosis, and personalized treatment strategies.