Functional connectivity between the habenula and posterior default mode network contributes to the response of the duloxetine effect in major depressive disorder.

IF 1.6 4区 医学 Q4 NEUROSCIENCES
Neuroreport Pub Date : 2024-04-03 Epub Date: 2024-03-01 DOI:10.1097/WNR.0000000000002019
Yanru Wu, Zhaosong Chu, Xianyu Chen, Yun Zhu, Xiufeng Xu, Zonglin Shen
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引用次数: 0

Abstract

This study aims to investigate the functional connectivity (FC) changes of the habenula (Hb) among patients with major depressive disorder (MDD) after 12 weeks of duloxetine treatment (MDD12). Patients who were diagnosed with MDD for the first time and were drug-naïve were recruited at baseline as cases. Healthy controls (HCs) matched for sex, age, and education level were also recruited at the same time. At baseline, all participants underwent resting-state functional MRI. FC analyses were performed using the Hb seed region of interest, and three groups including HCs, MDD group and MDD12 group were compared using whole-brain voxel-wise comparisons. Compared to the HCs, the MDD group had decreased FC between the Hb and the right anterior cingulate cortex at baseline. Compared to the HCs, the FC between the Hb and the left medial superior frontal gyrus decreased in the MDD12 group. Additionally, the FC between the left precuneus, bilateral cuneus and Hb increased in the MDD12 group than that in the MDD group. No significant correlation was found between HDRS-17 and the FC between the Hb, bilateral cuneus, and the left precuneus in the MDD12 group. Our study suggests that the FC between the post-default mode network and Hb may be the treatment mechanism of duloxetine and the treatment mechanisms and the pathogenesis of depression may be independent of each other.

哈伯小脑和后部默认模式网络之间的功能连接有助于重度抑郁障碍患者对度洛西汀效应的反应。
本研究旨在探讨重度抑郁障碍(MDD)患者在接受 12 周度洛西汀治疗(MDD12)后,哈伯脑(Hb)的功能连接性(FC)变化。研究招募了首次被诊断为重度抑郁障碍(MDD)且未接受过药物治疗的患者作为基线病例。同时还招募了性别、年龄和教育程度相匹配的健康对照组(HCs)。基线时,所有参与者都接受了静息态功能磁共振成像检查。使用 Hb 种子感兴趣区进行 FC 分析,并使用全脑体素比较法对包括 HCs、MDD 组和 MDD12 组在内的三组进行比较。与 HCs 相比,MDD 组在基线时 Hb 与右前扣带回皮层之间的 FC 值降低。与普通人群相比,MDD12 组的 Hb 与左侧内侧额上回之间的 FC 有所下降。此外,与 MDD 组相比,MDD12 组患者左侧楔前叶、双侧楔叶和 Hb 之间的 FC 增加。在 MDD12 组中,HDRS-17 与 Hb、双侧楔丘和左侧楔前丘之间的 FC 之间没有发现明显的相关性。我们的研究表明,后默认模式网络与Hb之间的FC可能是度洛西汀的治疗机制,而治疗机制与抑郁症的发病机制可能是相互独立的。
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来源期刊
Neuroreport
Neuroreport 医学-神经科学
CiteScore
3.20
自引率
0.00%
发文量
150
审稿时长
1 months
期刊介绍: NeuroReport is a channel for rapid communication of new findings in neuroscience. It is a forum for the publication of short but complete reports of important studies that require very fast publication. Papers are accepted on the basis of the novelty of their finding, on their significance for neuroscience and on a clear need for rapid publication. Preliminary communications are not suitable for the Journal. Submitted articles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool. The core interest of the Journal is on studies that cast light on how the brain (and the whole of the nervous system) works. We aim to give authors a decision on their submission within 2-5 weeks, and all accepted articles appear in the next issue to press.
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