Risk factors associated with heatwave mortality in Chinese adults over 65 years

IF 50 1区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Di Xi, Linxin Liu, Min Zhang, Cunrui Huang, Katrin G. Burkart, Kristie Ebi, Yi Zeng, John S. Ji
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Abstract

Aging populations are susceptible to heat-related mortality because of physiological factors and comorbidities. However, the understanding of individual vulnerabilities in the aging population is incomplete. In the Chinese Longitudinal Healthy Longevity Survey, we assessed daily heatwave exposure individually for 13,527 participants (median age = 89 years) and 3,249 summer mortalities during follow-up from 2008 to 2018. The mortality risk during heatwave days according to relative temperature is approximately doubled (hazard ratio (HR) range = 1.78–1.98). We found that heatwave mortality risks were increased for individuals with functional declines in mobility (HR range = 2.32–3.20), dependency in activities of daily living (HR range = 2.22–3.27), cognitive impairment (HR = 2.22) and social isolation reflected by having nobody to ask for help during difficulties (HR range = 2.14–10.21). Contrary to current understanding, older age was not predictive of heatwave mortality risk after accounting for individual functional declines; no statistical differences were detected according to sex. Beyond age as a risk factor, our findings emphasize that functional aging is an underlying factor in enhancing heatwave resilience. Assessment of functional decline and implementing care strategies are crucial for targeted prevention of mortality during heatwaves. In a prospective cohort of Chinese participants aged 65 years and older, heatwaves doubled the risk of mortality, especially in adults with functional impairments and dependency on daily living activities.

Abstract Image

Abstract Image

中国 65 岁以上成年人热浪死亡的相关风险因素。
由于生理因素和合并症,老年人群很容易因高温而死亡。然而,人们对老龄人口个体脆弱性的了解并不全面。在中国健康长寿纵向调查中,我们对13527名参与者(中位年龄=89岁)的每日热浪暴露进行了单独评估,并在2008年至2018年的随访期间评估了3249例夏季死亡病例。根据相对温度,热浪天的死亡风险大约增加一倍(危险比 (HR) 范围 = 1.78-1.98)。我们发现,对于行动能力下降(HR 范围 = 2.32-3.20)、日常生活活动依赖(HR 范围 = 2.22-3.27)、认知障碍(HR = 2.22)和社会孤立(HR 范围 = 2.14-10.21)的人来说,热浪死亡风险增加。与目前的认识相反,在考虑了个人功能衰退的因素后,年龄较大并不能预测热浪的死亡风险;没有发现性别方面的统计差异。除了年龄这一风险因素外,我们的研究结果还强调,功能衰退是增强热浪适应能力的一个潜在因素。评估功能衰退和实施护理策略对于有针对性地预防热浪期间的死亡至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Nature Medicine
Nature Medicine 医学-生化与分子生物学
CiteScore
100.90
自引率
0.70%
发文量
525
审稿时长
1 months
期刊介绍: Nature Medicine is a monthly journal publishing original peer-reviewed research in all areas of medicine. The publication focuses on originality, timeliness, interdisciplinary interest, and the impact on improving human health. In addition to research articles, Nature Medicine also publishes commissioned content such as News, Reviews, and Perspectives. This content aims to provide context for the latest advances in translational and clinical research, reaching a wide audience of M.D. and Ph.D. readers. All editorial decisions for the journal are made by a team of full-time professional editors. Nature Medicine consider all types of clinical research, including: -Case-reports and small case series -Clinical trials, whether phase 1, 2, 3 or 4 -Observational studies -Meta-analyses -Biomarker studies -Public and global health studies Nature Medicine is also committed to facilitating communication between translational and clinical researchers. As such, we consider “hybrid” studies with preclinical and translational findings reported alongside data from clinical studies.
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