Prevalence and Determinants of Cervicovaginal, Oral, and Anal Human Papillomavirus Infection in a Population of Transgender and Gender Diverse People Assigned Female at Birth.

IF 3.9 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
LGBT health Pub Date : 2024-08-01 Epub Date: 2024-03-25 DOI:10.1089/lgbt.2023.0335
Ryan D McIntosh, Emily C Andrus, Heather M Walline, Claire B Sandler, Christine M Goudsmit, Molly B Moravek, Daphna Stroumsa, Shanna K Kattari, Andrew F Brouwer
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引用次数: 0

Abstract

Purpose: The human papillomavirus (HPV) causes cervicovaginal, oral, and anogenital cancer, and cervical cancer screening options include HPV testing of a clinician-collected sample. Transgender and gender diverse (TGD) people assigned female at birth (AFAB) face many barriers to preventive care, including cancer screening. Self-sampling options may increase access and participation in HPV testing and cancer screening. This study estimated the prevalence of HPV in self-collected cervicovaginal, oral, and anal samples from Midwestern TGD individuals AFAB. Methods: We recruited TGD individuals AFAB for an observational study, mailing them materials to self-collect cervicovaginal, oral, and anal samples at home. We tested samples for high-risk (HR; 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59) and other HPV genotypes (6, 11, 66, 68, 73, 90) using a polymerase chain reaction mass array test. Prevalence ratios for HPV infection at each site as a function of participant characteristics were estimated in log-binomial models. Results: Out of 137 consenting participants, 102 completed sample collection. Among those with valid tests, 8.8% (HR = 6.6%; HPV 16/18 = 3.3%) were positive for oral HPV, 30.5% (HR = 26.8%; HPV 16/18 = 9.7%) for cervicovaginal HPV, and 39.6% (HR = 33.3%; HPV 16/18 = 8.3%) for anal HPV. A larger fraction of oral (71.4%) than anal infections (50.0%) were concordant with a cervicovaginal infection of the same type. Conclusions: We detected HR cervicovaginal, oral, and anal HPV in TGD people AFAB. It is essential that we reduce barriers to cancer screening for TGD populations, such as through the development of a clinically approved self-screening HPV test.

出生时被指定为女性的变性人和性别多元化人群宫颈阴道、口腔和肛门人类乳头瘤病毒感染的流行率和决定因素》(Prevalence and Determinants of Cervicovaginal, Oral, and Anal Human Papillomavirus Infection in a Population of Transgender and Gender Diverse People Assigned Female at Birth)。
目的:人类乳头瘤病毒(HPV)可导致宫颈阴道癌、口腔癌和肛门癌,宫颈癌筛查方法包括对临床医生采集的样本进行 HPV 检测。出生时即被指派为女性的变性人和性别多元化(TGD)人群在接受预防性护理(包括癌症筛查)时面临许多障碍。自我采样方案可提高 HPV 检测和癌症筛查的可及性和参与度。本研究估算了中西部 TGD 无性恋者自采宫颈阴道、口腔和肛门样本中 HPV 的流行率。方法:我们为一项观察性研究招募了无肛门指诊的 TGD 患者,并向他们邮寄了在家自行采集宫颈阴道、口腔和肛门样本的材料。我们使用聚合酶链式反应质量阵列测试对样本进行了高风险(HR;16、18、31、33、35、39、45、51、52、56、58、59)和其他 HPV 基因型(6、11、66、68、73、90)检测。在对数二项式模型中估算了每个部位的 HPV 感染流行率与参与者特征的函数关系。结果显示在 137 名同意的参与者中,102 人完成了样本采集。在有效检测中,8.8%(HR = 6.6%;HPV 16/18 = 3.3%)口腔 HPV 阳性,30.5%(HR = 26.8%;HPV 16/18 = 9.7%)宫颈阴道 HPV 阳性,39.6%(HR = 33.3%;HPV 16/18 = 8.3%)肛门 HPV 阳性。口腔感染(71.4%)比肛门感染(50.0%)与同类型宫颈阴道感染的比例更高。结论:我们在同性恋、双性恋和变性者中检测到了 HR 宫颈阴道、口腔和肛门 HPV。我们必须减少 TGD 群体癌症筛查的障碍,例如通过开发临床认可的自我筛查 HPV 测试。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
LGBT health
LGBT health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH -
CiteScore
6.60
自引率
6.20%
发文量
80
期刊介绍: LGBT Health is the premier peer-reviewed journal dedicated to promoting optimal healthcare for millions of sexual and gender minority persons worldwide by focusing specifically on health while maintaining sufficient breadth to encompass the full range of relevant biopsychosocial and health policy issues. This Journal aims to promote greater awareness of the health concerns particular to each sexual minority population, and to improve availability and delivery of culturally appropriate healthcare services. LGBT Health also encourages further research and increased funding in this critical but currently underserved domain. The Journal provides a much-needed authoritative source and international forum in all areas pertinent to LGBT health and healthcare services. Contributions from all continents are solicited including Asia and Africa which are currently underrepresented in sex research.
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