Predictive factors of periodontal regeneration outcomes using rhFGF-2: A case–control study

IF 3.4 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of periodontal research Pub Date : 2024-03-25 DOI:10.1111/jre.13259

Shinji Matsuda, Tomoya Ueda, Fuminori Nakashima, Yurika Ninomiya, Keisuke Yasuda, Shinya Sasaki, Yuta Hamamoto, Tomoyuki Iwata, Kazuhisa Ouhara, Naoki Mihara, Naoya Kakimoto, Noriyoshi Mizuno

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引用次数: 0

Abstract

Objective

This study aimed to investigate the factors influencing the clinical outcomes of regenerative therapy using recombinant human fibroblast growth factor-2 (rhFGF-2).

Background

rhFGF-2 promotes periodontal regeneration, and identifying the factors influencing this regeneration is important for optimizing the effectiveness of rhFGF-2.

Methods and Materials

This study used a hospital information-integrated database to identify patients who underwent periodontal regenerative therapy with rhFGF-2. Factors included age, smoking status, diabetes mellitus (DM), periodontal inflamed surface area (PISA) at the initial visit, whether the most posterior tooth was involved or not, and preoperative radiological bone defect angle. Periodontal regenerative therapy outcomes were defined as good if radiographic bone fill ≥35% or periodontal pocket closure at 9–15 months after surgery. Bone fill rate (%) and periodontal pocket depth (mm) were also used as outcome measures. Factors were evaluated by simple regression analysis, and then the association between factors and the outcomes was determined by multivariate analysis.

Results

PISA and age at the first visit did not significantly influence the success or failure of bone fill rate byrhFGF-2. However, DM, radiographic bone defect angle, and the most posterior tooth significantly influenced the regenerative effect (success/failure in bone fill) of rhFGF-2. The most posterior tooth was significantly associated with bone fill rate by rhFGF-2. Examination of the association between pocket closure and factors shows that the most posterior tooth significantly influenced. The most posterior tooth and preoperative PPD were significantly associated with pocket reduction depth. For the most posterior tooth, a significantly higher bone regeneration rate (p < .05) was observed with a combination of autologous bone graft and rhFGF-2 than with rhFGF-2 alone, and the effect was significant in multivariate analysis.

Conclusions

The radiographic bone defect angle, the involvement of most posterior teeth, and the presence of DM influenced the effectiveness of rhFGF-2 in periodontal regeneration. However, PISA values and age at the initial visit had no significant effect.

Abstract Image

查看原文本刊更多论文

使用 rhFGF-2 进行牙周再生结果的预测因素：一项病例对照研究。

背景：rhFGF-2能促进牙周再生：背景：rhFGF-2能促进牙周再生，确定影响牙周再生的因素对于优化rhFGF-2的疗效非常重要：本研究使用医院信息集成数据库来识别接受 rhFGF-2 牙周再生治疗的患者。影响因素包括年龄、吸烟状况、糖尿病（DM）、初诊时的牙周炎症表面积（PISA）、最后排牙齿是否受累以及术前放射学骨缺损角度。如果术后 9-15 个月的放射骨填充率≥35% 或牙周袋闭合，则定义牙周再生治疗效果为良好。骨填充率（%）和牙周袋深度（毫米）也被用作衡量结果的指标。通过简单回归分析评估各因素，然后通过多变量分析确定各因素与结果之间的关联：结果：PISA和首次就诊时的年龄对使用rhFGF-2进行骨填充的成败没有明显影响。然而，DM、放射学骨缺损角度和最后排牙齿对 rhFGF-2 的再生效果（骨填充成功/失败）有显著影响。最靠后的牙齿与 rhFGF-2 的骨填充率明显相关。对牙槽骨闭合与各种因素之间关系的研究表明，最后排的牙齿对牙槽骨闭合有明显影响。最后牙和术前 PPD 与牙槽袋缩小深度有显著相关性。最后排牙齿的骨再生率明显更高（p 结论：最后排牙齿的骨再生率明显高于最前排牙齿：影像学骨缺损角度、多数后牙受累以及 DM 的存在都会影响 rhFGF-2 在牙周再生中的效果。然而，PISA 值和初次就诊时的年龄没有显著影响。

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来源期刊

Journal of periodontal research 医学-牙科与口腔外科

CiteScore

6.90

自引率

5.70%

发文量

103

审稿时长

6-12 weeks

期刊介绍： The Journal of Periodontal Research is an international research periodical the purpose of which is to publish original clinical and basic investigations and review articles concerned with every aspect of periodontology and related sciences. Brief communications (1-3 journal pages) are also accepted and a special effort is made to ensure their rapid publication. Reports of scientific meetings in periodontology and related fields are also published. One volume of six issues is published annually.