Single nucleotide polymorphisms of ANKK1, DDR4, and GRIN2B genes predict behavior in a prospective cohort of Mexican children and adolescents

IF 1.7 4区 医学 Q3 DEVELOPMENTAL BIOLOGY
Barbara Moctezuma MSc, Ángel Santiago PhD, Ana Burguete-García MD, ScD, Jesus Martínez-Barnetche MD, PhD, Claudia Morales-Gómez MSc, Carmen Hernandez-Chavez PhD, Gabriela Gil BSc, Karen E. Peterson PhD, Martha M. Tellez-Rojo ScD, Hector Lamadrid-Figueroa MD, ScD
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Abstract

Numerous studies have established associations between single nucleotide polymorphisms (SNPs) and various behavioral and neurodevelopmental conditions. This study explores the links between SNPs in candidate genes involved in central nervous system (CNS) physiology and their implications for the behavioral and emotional aspects in children and teenagers. A total of 590 participants, aged 7–15 years, from the Early Life Exposures In Mexico To Environmental Toxicants (ELEMENT) cohort study in Mexico City, underwent genotyping for at least one of 15 CNS gene-related SNPs at different timepoints. We employed multiple linear regression models to assess the potential impact of genetic variations on behavioral and cognitive traits, as measured by the Behavioral Assessment System for Children (BASC) and Conners parent rating scales. Significant associations were observed, including the rs1800497 TC genotype (ANKK1) with the Cognitive Problems/Inattention variable (p value = 0.003), the rs1800955 CT genotype (DDR4) with the Emotional Lability Global index variable (p value = 0.01), and the rs10492138 GA and rs7970177 TC genotypes (GRIN2B) with the Depression variable (p values 0.007 and 0.012, respectively). These finds suggest potential genetic profiles associated with “risk” and “protective” behaviors for these SNPs. Our results provide valuable insights into the role of genetic variations in neurobehavior and highlight the need for further research in the early identification and intervention in individuals at risk for these conditions.

Abstract Image

墨西哥儿童和青少年前瞻性队列中 ANKK1、DDR4 和 GRIN2B 基因的单核苷酸多态性可预测行为。
许多研究已经证实了单核苷酸多态性(SNPs)与各种行为和神经发育状况之间的关联。本研究探讨了参与中枢神经系统(CNS)生理学的候选基因中的 SNPs 与儿童和青少年行为和情绪方面的影响之间的联系。共有 590 名 7-15 岁的参与者参加了墨西哥城的 "墨西哥早期环境毒物暴露(ELEMENT)队列研究",他们在不同的时间点对 15 个中枢神经系统相关基因 SNPs 中的至少一个进行了基因分型。我们采用多元线性回归模型来评估基因变异对行为和认知特征的潜在影响,这些特征是通过儿童行为评估系统(BASC)和康纳斯家长评分量表来测量的。研究发现,rs1800497 TC 基因型(ANKK1)与认知问题/注意力不集中变量(p 值 = 0.003)、rs1800955 CT 基因型(DDR4)与情绪不稳定性全球指数变量(p 值 = 0.01)、rs10492138 GA 和 rs7970177 TC 基因型(GRIN2B)与抑郁变量(p 值分别为 0.007 和 0.012)存在显著关联。这些发现表明,这些 SNPs 可能具有与 "风险 "和 "保护 "行为相关的遗传特征。我们的研究结果为了解遗传变异在神经行为中的作用提供了宝贵的见解,并强调了进一步研究早期识别和干预高危人群的必要性。
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来源期刊
CiteScore
3.30
自引率
5.60%
发文量
78
审稿时长
6-12 weeks
期刊介绍: International Journal of Developmental Neuroscience publishes original research articles and critical review papers on all fundamental and clinical aspects of nervous system development, renewal and regeneration, as well as on the effects of genetic and environmental perturbations of brain development and homeostasis leading to neurodevelopmental disorders and neurological conditions. Studies describing the involvement of stem cells in nervous system maintenance and disease (including brain tumours), stem cell-based approaches for the investigation of neurodegenerative diseases, roles of neuroinflammation in development and disease, and neuroevolution are also encouraged. Investigations using molecular, cellular, physiological, genetic and epigenetic approaches in model systems ranging from simple invertebrates to human iPSC-based 2D and 3D models are encouraged, as are studies using experimental models that provide behavioural or evolutionary insights. The journal also publishes Special Issues dealing with topics at the cutting edge of research edited by Guest Editors appointed by the Editor in Chief. A major aim of the journal is to facilitate the transfer of fundamental studies of nervous system development, maintenance, and disease to clinical applications. The journal thus intends to disseminate valuable information for both biologists and physicians. International Journal of Developmental Neuroscience is owned and supported by The International Society for Developmental Neuroscience (ISDN), an organization of scientists interested in advancing developmental neuroscience research in the broadest sense.
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