Bacterial cholesterol-dependent cytolysins and their interaction with the human immune response.

IF 3.6 3区医学 Q2 INFECTIOUS DISEASES

Current Opinion in Infectious Diseases Pub Date : 2024-06-01 Epub Date: 2024-03-21 DOI:10.1097/QCO.0000000000001010

Tristan C Sanford, Rodney K Tweten, Hunter L Abrahamsen

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引用次数: 0

Abstract

Purpose of review: Many cholesterol-dependent cytolysin (CDC)-producing pathogens pose a significant threat to human health. Herein, we review the pore-dependent and -independent properties CDCs possess to assist pathogens in evading the host immune response.

Recent findings: Within the last 5 years, exciting new research suggests CDCs can act to inhibit important immune functions, disrupt critical cell signaling pathways, and have tissue-specific effects. Additionally, recent studies have identified a key region of CDCs that generates robust immunity, providing resources for the development of CDC-based vaccines.

Summary: This review provides new information on how CDCs alter host immune responses to aid bacteria in pathogenesis. These studies can assist in the design of more efficient vaccines and therapeutics against CDCs that will enhance the immune response to CDC-producing pathogens while mitigating the dampening effects CDCs have on the host immune response.

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依赖胆固醇的细菌细胞溶解素及其与人类免疫反应的相互作用。

审查目的：许多产生胆固醇依赖性细胞溶解素（CDC）的病原体对人类健康构成重大威胁。在此，我们回顾了 CDC 依赖孔和不依赖孔的特性，这些特性可帮助病原体逃避宿主的免疫反应：在过去 5 年中，令人兴奋的新研究表明 CDCs 可抑制重要的免疫功能、破坏关键的细胞信号通路，并具有组织特异性效应。此外，最近的研究还发现了 CDCs 产生强大免疫力的一个关键区域，为开发基于 CDC 的疫苗提供了资源。这些研究有助于针对 CDCs 设计更有效的疫苗和疗法，从而增强对 CDC 产生的病原体的免疫反应，同时减轻 CDCs 对宿主免疫反应的抑制作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Infectious Diseases 医学-传染病学

CiteScore

6.70

自引率

2.60%

发文量

121

审稿时长

6-12 weeks

期刊介绍： This reader-friendly, bimonthly resource provides a powerful, broad-based perspective on the most important advances from throughout the world literature. Featuring renowned guest editors and focusing exclusively on two topics, every issue of Current Opinion in Infectious Disease delivers unvarnished, expert assessments of developments from the previous year. Insightful editorials and on-the-mark invited reviews cover key subjects such as HIV infection and AIDS; skin and soft tissue infections; respiratory infections; paediatric and neonatal infections; gastrointestinal infections; tropical and travel-associated diseases; and antimicrobial agents.