Obesity and Obesity-Related Thyroid Dysfunction: Any Potential Role for the Very Low-Calorie Ketogenic Diet (VLCKD)?

IF 4.6 3区医学 Q1 NUTRITION & DIETETICS

Current Nutrition Reports Pub Date : 2024-06-01 Epub Date: 2024-03-25 DOI:10.1007/s13668-024-00528-w

Sebastián Pablo Chapela, Alison Simancas-Racines, Florencia Ceriani, Andrés Luciano Nicolas Martinuzzi, María Paula Russo, Ana Karina Zambrano, Daniel Simancas-Racines, Ludovica Verde, Giovanna Muscogiuri, Christos S Katsanos, Evelyn Frias-Toral, Luigi Barrea

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Abstract

Purpose of review: This review aims to explore in-depth the different aspects of the association between very low-calorie ketogenic diet (VLCKD), obesity and obesity-related thyroid dysfunction.

Recent findings: The VLCKD, proposed as a non-pharmacological strategy for the management of certain chronic diseases, is becoming increasingly popular worldwide. Initially used to treat epilepsy, it has been shown to be effective in controlling body weight gain and addressing various pathophysiological conditions. Research has shown that a low-calorie, high-fat diet can affect thyroid hormone levels. Weight loss can also influence thyroid hormone levels. Studies have suggested that long-term use of VLCKD for refractory epilepsy may be related to the development of hypothyroidism, with an effect seen in various populations. In particular, women with obesity following VLCKD tend to have reduced T3 levels. We propose further research to unravel the underlying mechanisms linking VLCKD to obesity and obesity-related thyroid dysfunction.

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肥胖与肥胖相关的甲状腺功能障碍：极低热量生酮饮食（VLCKD）的潜在作用？

综述目的：本综述旨在深入探讨超低卡路里生酮饮食（VLCKD）、肥胖和肥胖相关甲状腺功能障碍之间的各方面关联：极低热量生酮饮食作为一种治疗某些慢性疾病的非药物疗法，在全世界越来越受欢迎。该疗法最初用于治疗癫痫，现已证明能有效控制体重增加并解决各种病理生理问题。研究表明，低热量、高脂肪饮食会影响甲状腺激素水平。减肥也会影响甲状腺激素水平。研究表明，长期使用 VLCKD 治疗难治性癫痫可能与甲状腺功能减退症的发生有关，这种影响可见于不同人群。尤其是肥胖的女性在使用 VLCKD 后，T3 水平往往会降低。我们建议开展进一步研究，以揭示VLCKD与肥胖和肥胖相关甲状腺功能障碍之间的内在机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Nutrition Reports Agricultural and Biological Sciences-Food Science

CiteScore

7.70

自引率

2.00%

发文量

期刊介绍： This journal aims to provide comprehensive review articles that emphasize significant developments in nutrition research emerging in recent publications. By presenting clear, insightful, balanced contributions by international experts, the journal intends to discuss the influence of nutrition on major health conditions such as diabetes, cardiovascular disease, cancer, and obesity, as well as the impact of nutrition on genetics, metabolic function, and public health. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas across the field. Section Editors select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. We also provide commentaries from well-known figures in the field, and an Editorial Board of more than 25 internationally diverse members reviews the annual table of contents, suggests topics of special importance to their country/region, and ensures that topics and current and include emerging research.