The development and the genetic diseases of the ciliary body

Baige Li , Ting Xie , Scott Nawy , Yin Shen
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引用次数: 0

Abstract

The ciliary body, located at the junction of the choroid and iris, is crucial in the development of the embryonic eye. Notch2 signalling, Wnt signalling, transforming growth factor β (TGF-β) signalling, and Pax6 signalling are critical for coordinating the ciliary body formation. These signalling pathways are coordinated with each other and participate in the ciliary body development, ensuring the precise formation and optimal functioning of the eye structure. Although rare, ciliary body hypoplasia, ciliary tumours, and genetic-related iritis indicate the intricate nature of ciliary body development. Given the ciliary body's important biological significance and potential medical relevance, we aim to provide a comprehensive overview of the developmental molecular mechanisms governing ciliary body formation and function. Here, we focus on the intricate signalling pathways governing ciliary body development and corresponding genetic ciliary diseases.

睫状体的发育和遗传疾病
睫状体位于脉络膜和虹膜的交界处,对胚胎眼球的发育至关重要。Notch2信号、Wnt信号、转化生长因子β(TGF-β)信号和Pax6信号对协调睫状体的形成至关重要。这些信号通路相互协调,共同参与睫状体的发育,确保眼睛结构的精确形成和最佳功能。睫状体发育不全、睫状体肿瘤和遗传性虹膜炎虽然罕见,但却表明了睫状体发育的复杂性。鉴于睫状体重要的生物学意义和潜在的医学相关性,我们旨在全面概述支配睫状体形成和功能的发育分子机制。在此,我们将重点关注支配睫状体发育和相应遗传性睫状体疾病的复杂信号通路。
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来源期刊
Cell insight
Cell insight Neuroscience (General), Biochemistry, Genetics and Molecular Biology (General), Cancer Research, Cell Biology
CiteScore
2.70
自引率
0.00%
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0
审稿时长
35 days
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