Zachary Congress , Jun Tae Huh , James Yoo , Sang Jin Lee , Shay Soker
{"title":"Augmented in vitro liver models with bioprinted liver organoids","authors":"Zachary Congress , Jun Tae Huh , James Yoo , Sang Jin Lee , Shay Soker","doi":"10.1016/j.cobme.2024.100531","DOIUrl":null,"url":null,"abstract":"<div><p>Bioprinted liver organoids (LOs) have emerged as a crucial tool for investigating patient-specific models and enhancing disease comprehension as well as overall patient care. These systems are comprised of liver-specific cell types along with suitable biomaterials to facilitate the printing process and provide a microenvironment for cell accommodation. Various printing technologies, such as jetting, extrusion, and stereolithography, each present distinct advantages and disadvantages concerning printing resolution, rheological properties, and biomaterial selection. Leveraging patient-derived cells, these models facilitate the development of personalized <em>in vitro</em> liver models, enabling the exploration of disease progression and drug efficacy. Advancing research on liver tissue-specific printable biomaterials and exploring designs that can effectively mimic the diverse functions of liver tissue will greatly expedite clinically relevant model development and augment patient care.</p></div>","PeriodicalId":36748,"journal":{"name":"Current Opinion in Biomedical Engineering","volume":null,"pages":null},"PeriodicalIF":4.7000,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Biomedical Engineering","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2468451124000114","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Bioprinted liver organoids (LOs) have emerged as a crucial tool for investigating patient-specific models and enhancing disease comprehension as well as overall patient care. These systems are comprised of liver-specific cell types along with suitable biomaterials to facilitate the printing process and provide a microenvironment for cell accommodation. Various printing technologies, such as jetting, extrusion, and stereolithography, each present distinct advantages and disadvantages concerning printing resolution, rheological properties, and biomaterial selection. Leveraging patient-derived cells, these models facilitate the development of personalized in vitro liver models, enabling the exploration of disease progression and drug efficacy. Advancing research on liver tissue-specific printable biomaterials and exploring designs that can effectively mimic the diverse functions of liver tissue will greatly expedite clinically relevant model development and augment patient care.