Relationship Between Coagulation and Prognosis of Gastric Cancer: A Systematic Review and Meta-Analysis

IF 1.6 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Current Therapeutic Research-clinical and Experimental Pub Date : 2024-01-01 DOI:10.1016/j.curtheres.2024.100741

Lihui Zhu , Shuo Liu , Da Wang , Miao Yu , Hui Cai

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引用次数: 0

Abstract

Background

The hypercoagulable state of cancer patients is associated with their high mortality rate. Coagulation indicators may have an important role in the prognosis of gastric cancer patients and deserve to be explored in various aspects.

Objective

We conducted a meta-analysis to explore the correlation between coagulation and prognosis of gastric cancer.

Methods

A comprehensive systematic search was conducted in PubMed, Embase, Web of Science databases, and the Cochrane Library up to February 16, 2024. Literature screening and data extraction were performed by two independent reviewers. The processed data we pooled using either a random-effects model or a fixed-effects model and finally described overall survival with a risk ratio (hazard ratio [HR]) and predicted the likelihood of different clinicopathological events with a dominance ratio (OR).

Results

A total of 64 studies were screened for inclusion in the data analysis. Performing a meta-analysis of three indicators we derived that the risk of d-dimer (D-D), fibrinogen (FIB), and platelets (PLTs) were: HR = 1.85 (95% confidence interval [CI]: 1.59–2.15, N = 15), HR = 1.77 (95% CI: 1.57–1.99, N = 28), HR = 1.16 (95% CI: 1.12–1.21, N = 29). In addition to this, all three were associated with advanced clinicopathological stage (D-D: OR = 2.25, FIB: OR = 2.07, PLT: OR = 1.84), T stage (D-D: OR = 2.30, FIB: OR = 2.38, PLT: OR = 2.22) and lymph node metastasis (D-D: OR = 1.79, FIB: OR = 1.70, PLT: OR = 1.51).

Conclusion

Overall, the findings suggest that the three indicators, D-D, FIB, and PLT count, have significant predictive value for the prognosis of gastric cancer. They were associated with an advanced clinicopathological stage and a high risk of lymph node metastasis.

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凝血与胃癌预后的关系：系统回顾与荟萃分析

背景癌症患者的高凝状态与其高死亡率有关。我们进行了一项荟萃分析，探讨凝血与胃癌预后之间的相关性。方法在 PubMed、Embase、Web of Science 数据库和 Cochrane 图书馆中进行了全面的系统检索，截至 2024 年 2 月 16 日。文献筛选和数据提取由两名独立审稿人完成。我们使用随机效应模型或固定效应模型对处理后的数据进行汇总，最后用风险比（危险比[HR]）描述总生存率，并用优势比（OR）预测不同临床病理事件发生的可能性。通过对三项指标进行荟萃分析，我们得出二聚体（D-D）、纤维蛋白原（FIB）和血小板（PLTs）的风险分别为HR = 1.85（95% 置信区间[CI]：1.59-2.15，N = 15）、HR = 1.77（95% 置信区间：1.57-1.99，N = 28）、HR = 1.16（95% 置信区间：1.12-1.21，N = 29）。除此之外，三者均与临床病理分期晚期（D-D：OR = 2.25，FIB：OR = 2.07，PLT：OR = 1.84）、T 期（D-D：OR = 2.30，FIB：OR = 2.38，PLT：OR = 2.总之，研究结果表明，D-D、FIB 和 PLT 计数这三个指标对胃癌的预后具有显著的预测价值。它们与临床病理分期的晚期和淋巴结转移的高风险相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Therapeutic Research-clinical and Experimental 医学-药学

CiteScore

3.50

自引率

0.00%

发文量

审稿时长

3 months

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