Bee venom acupuncture and herbal medicine for hand eczema: Two case reports and an in vivo study

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-03-21 DOI:10.1016/j.explore.2024.03.002

Soobin Jang , Hyo In Kim , Jae Woo Jung , Mina Boo , Soo-Hyun Sung , Jinbong Park , Sungha Kim

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引用次数: 0

Abstract

Introduction

Eczema and contact dermatitis are relatively common, non-life-threatening disease, but can reduce the patient's quality-of-life when it becomes chronic. This study describes two cases of bee venom acupuncture (BVA) and herbal medicine (San Wu Huangqin decoction; SWH) co-treatment for hand eczema and contact dermatitis, then confirms the effect of the combination therapy in an in vivo model of eczema.

Case presentation

A 56-year-old female (case 1) and a 33-year-old male (case 2) presented to the clinic with symptoms of itching and erythema (case 1), and scaliness (case 2) on both hands. Both were diagnosed with hand eczema and contact dermatitis based on examination of the erythema and scaliness. They were treated with BVA and SWH for three months. The lesions were healed and had not recurred after 1 and 3 years of follow-up. A mouse study was conducted by repeated application of 2,4-dinitrochlorobenzene (DNCB) to induce eczema-like contact dermatitis in Balb/c mice. In a DNCB-induced eczema-like contact dermatitis model, BVA and SWH co-administration synergistically improved clinical symptoms seen in eczema. Also, they improved histological changes of the skin, suppressed immune cell infiltration, and decreased inflammatory cytokines and immunoglobulin E in the serum.

Conclusion

This study suggests BVA and SWH could be an alternative treatment for eczema and contact dermatitis.

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蜂毒针灸和中药治疗手部湿疹：两个病例报告和一项体内研究

引言湿疹和接触性皮炎是比较常见的疾病，不会危及生命，但一旦转为慢性，会降低患者的生活质量。本研究描述了两例蜂毒针刺（BVA）和中药（三五黄芩汤；SWH）联合治疗手部湿疹和接触性皮炎的病例，然后在湿疹的活体模型中证实了联合治疗的效果。病例介绍56岁的女性（病例1）和33岁的男性（病例2）因双手瘙痒、红斑（病例1）和鳞屑（病例2）症状就诊。根据红斑和鳞屑的检查结果，两人都被诊断为手部湿疹和接触性皮炎。他们接受了为期三个月的 BVA 和 SWH 治疗。经过 1 年和 3 年的随访，皮损痊愈且未复发。一项小鼠研究通过反复使用 2,4-二硝基氯苯（DNCB）来诱发 Balb/c 小鼠湿疹样接触性皮炎。在 DNCB 诱导的湿疹样接触性皮炎模型中，联合使用 BVA 和 SWH 可协同改善湿疹的临床症状。结论这项研究表明，BVA 和 SWH 可以作为湿疹和接触性皮炎的替代治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.