Enzymes, auxiliaries, and cells for the recycling and upcycling of polyethylene terephthalate

IF 3.4 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Thanakrit Wongsatit , Thanate Srimora , Cholpisit Kiattisewee , Chayasith Uttamapinant
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引用次数: 0

Abstract

Biological recycling and valorization of plastics are promising approaches to solve global plastic waste accumulation. Out of diverse plastic materials, polyethylene terephthalate (PET) is one of the most abundant polymers with rapid development in both biodegradation and product upcycling. In this perspective, we review recent discoveries and engineering of PET-degrading enzymes together with plausible auxiliary pathways, and provide insights on how to construct better parts through systematic bioengineering (metagenome mining, protein design, and directed evolution). Then, we discuss the potential of microbial-based PET degradation and upcycling in either a single host or consortia, as well as bottom-up and top-down methods of microbial consortia engineering using novel synthetic biology tools for enhanced PET circularization.

用于聚对苯二甲酸乙二酯(PET)回收和再循环的酶、助剂和细胞
塑料的生物回收利用和增值是解决全球塑料废物积累问题的有效方法。在各种塑料材料中,聚对苯二甲酸乙二醇酯(PET)是最丰富的聚合物之一,在生物降解和产品升级再循环方面发展迅速。在这一视角中,我们回顾了最近发现的聚对苯二甲酸乙二醇酯降解酶和工程设计,以及可信的辅助途径,并就如何通过系统生物工程(元基因组挖掘、蛋白质设计和定向进化)构建更好的部件提供了见解。然后,我们讨论了单个宿主或联合体中基于微生物的 PET 降解和升级循环的潜力,以及利用新型合成生物学工具进行微生物联合体工程的自下而上和自上而下的方法,以增强 PET 循环。
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来源期刊
Current Opinion in Systems Biology
Current Opinion in Systems Biology Mathematics-Applied Mathematics
CiteScore
7.10
自引率
2.70%
发文量
20
期刊介绍: Current Opinion in Systems Biology is a new systematic review journal that aims to provide specialists with a unique and educational platform to keep up-to-date with the expanding volume of information published in the field of Systems Biology. It publishes polished, concise and timely systematic reviews and opinion articles. In addition to describing recent trends, the authors are encouraged to give their subjective opinion on the topics discussed. As this is such a broad discipline, we have determined themed sections each of which is reviewed once a year. The following areas will be covered by Current Opinion in Systems Biology: -Genomics and Epigenomics -Gene Regulation -Metabolic Networks -Cancer and Systemic Diseases -Mathematical Modelling -Big Data Acquisition and Analysis -Systems Pharmacology and Physiology -Synthetic Biology -Stem Cells, Development, and Differentiation -Systems Biology of Mold Organisms -Systems Immunology and Host-Pathogen Interaction -Systems Ecology and Evolution
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