Potential of Legetan Leaves (Acmella oleracea) as a Therapeutic Modality for Osteoarthritis: An In Vivo Study

I. Indrayani
{"title":"Potential of Legetan Leaves (Acmella oleracea) as a Therapeutic Modality for Osteoarthritis: An In Vivo Study","authors":"I. Indrayani","doi":"10.37275/ehi.v5i2.117","DOIUrl":null,"url":null,"abstract":"Introduction: Osteoarthritis (OA) is a degenerative joint disease characterized by inflammation and cartilage damage. Legetan leaves (Acmella oleracea) have anti-inflammatory and antioxidant potential that may help relieve OA symptoms. This study aims to evaluate the potential of legetan leaves as a therapeutic modality for OA in a rat model. \nMethods: Legetan leaf extract was formulated into an oral preparation and given to rats induced by OA with monosodium iodate. The positive control group received standard OA medications. Parameters measured include pain scores, joint inflammation, and cartilage damage. \nResults: Legetan leaf extract significantly reduced pain scores and joint inflammation in rats with OA. Legetan leaf extract also shows a protective effect against cartilage damage. \nConclusion: Legetan leaves have potential as a therapeutic modality for OA.","PeriodicalId":510746,"journal":{"name":"Eureka Herba Indonesia","volume":"93 5","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Eureka Herba Indonesia","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.37275/ehi.v5i2.117","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Introduction: Osteoarthritis (OA) is a degenerative joint disease characterized by inflammation and cartilage damage. Legetan leaves (Acmella oleracea) have anti-inflammatory and antioxidant potential that may help relieve OA symptoms. This study aims to evaluate the potential of legetan leaves as a therapeutic modality for OA in a rat model. Methods: Legetan leaf extract was formulated into an oral preparation and given to rats induced by OA with monosodium iodate. The positive control group received standard OA medications. Parameters measured include pain scores, joint inflammation, and cartilage damage. Results: Legetan leaf extract significantly reduced pain scores and joint inflammation in rats with OA. Legetan leaf extract also shows a protective effect against cartilage damage. Conclusion: Legetan leaves have potential as a therapeutic modality for OA.
乐果叶(Acmella oleracea)作为骨关节炎治疗方法的潜力:体内研究
简介骨关节炎(OA)是一种以炎症和软骨损伤为特征的退行性关节疾病。莱菔子叶(Acmella oleracea)具有抗炎和抗氧化潜力,可帮助缓解 OA 症状。本研究的目的是在大鼠模型中评估乐果叶作为治疗 OA 方法的潜力。研究方法将勒盖坦叶提取物配制成口服制剂,给大鼠服用,用碘酸钠诱导大鼠产生 OA。阳性对照组接受标准 OA 药物治疗。测量参数包括疼痛评分、关节炎症和软骨损伤。结果雷公藤叶提取物能明显降低患 OA 大鼠的疼痛评分和关节炎症。乐果叶提取物还对软骨损伤有保护作用。结论雷公藤叶具有治疗 OA 的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信