MEGALOBLASTIC ANEMIA IN ADULTS WITH NEW-ONSET PANCYTOPENIA ON PERIPHERAL SMEAR

Journal of Medical Sciences Pub Date : 2024-03-07 DOI:10.52764/jms.24.32.1.4

Sajid Razaq, A. Badshah, Obaid Ur Rehman, Nayab Munib, Mohsin Shafi

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Abstract

Objectives: To determine the frequency of megaloblastic anemia in patients with a new onset of pancytopenia on peripheral smear. Materials and Methods: This cross-sectional study was conducted in the Department of Medicine, Khyber Teaching Hospital, Peshawar from 1st February 2021 to 31st July 2021. A total of 109 patients participated in the study after fulfilling the inclusion criteria. Patients with pancytopenia on peripheral smear underwent bone marrow biopsy. Megaloblastic anemia as the cause of pancytopenia was confirmed after bone marrow biopsy reports were available. The results were stratified into tables based on study participants’ demographics. Data was analyzed by SPSS 23 and presented in tables. Results: Megaloblastic anemia was observed in 42.2% of patients presenting with pancytopenia on peripheral smear. 66.1% of these were male and 33.9% were female. Conclusion: A large number of patients with pancytopenia on initial investigations were diagnosed to be suffering from megaloblastic anemia in our study. Keywords: Pancytopenia; Megaloblastic anemia; Peripheral smear; Bone marrow biopsy

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外周血涂片显示新发泛血细胞减少的成人巨幼红细胞性贫血

目的确定外周涂片显示新发泛红细胞性贫血患者中巨幼红细胞性贫血的发生率：这项横断面研究于 2021 年 2 月 1 日至 2021 年 7 月 31 日在白沙瓦开伯尔教学医院内科进行。共有 109 名符合纳入标准的患者参与了研究。外周涂片显示全血细胞减少的患者接受了骨髓活检。在获得骨髓活检报告后，确认巨幼红细胞性贫血是导致全血细胞减少的原因。研究结果根据参与者的人口统计学特征分层列表。数据采用 SPSS 23 进行分析，并以表格形式呈现：结果：42.2%的患者在外周涂片上出现全血细胞减少症，其中 66.1%为男性。其中 66.1%为男性，33.9%为女性：结论：在我们的研究中，大量初步检查为全血细胞减少的患者被诊断为巨幼红细胞性贫血：全血细胞减少；巨幼细胞贫血；外周血涂片；骨髓活检

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Journal of Medical Sciences

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