Synthesis, spectroscopic and biological characterizations of platinum(IV), ruthenium(III) and iridium(III) theophylline complexes

IF 1.3 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Bulletin of the Chemical Society of Ethiopia Pub Date : 2024-03-12 DOI:10.4314/bcse.v38i3.14

Abeer A. El-Habeeb, M. S. Refat

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引用次数: 0

Abstract

This study used micro-analyses, (FTIR, UV-Vis) spectra, magnetic, thermogravimetric, X-ray powder diffraction (XRD) patterns, and transmittance electron microscopy (TEM) techniques to characterize three synthesized theophylline (TPH) complexes with ruthenium(III), platinum(IV), and iridium(III) metal ions. The metal ions indicated above were found to align with the TPH drug chelate as a mono-dentate ligand via the deprotonated NH group at the nitrogen atom position N7, as verified by FTIR measurements. Additionally, the complexes conductivity and magnetic susceptibility were examined. The octahedral geometry for the synthesized complexes was proposed by the current data. Except for the iridium(III) complex, which has a non-electrolytic nature due to the presence of a chlorine atom inside the chelation sphere, the molar conductivity of the complexes in DMSO solution was electrolyte in nature. Theophylline complexes with a (metal: ligand) stoichiometry of 1:2 were produced. The TPH complexes have also been tested in vitro against G(+) bacteria (Bacillus subtilis and Staphylococcus Aureus) and G(-) bacteria (Pseudomonas aeruginosa and Escherichia coli) to evaluate their antibacterial efficacy. Human breast and liver cancer cell lines were used as a test for the TPH complexes in vitro anti-cancer properties. KEY WORDS: Theophylline, Metal ions, Chelation, Octahedral, Spectral analysis, Nano-particles, Biological evaluation Bull. Chem. Soc. Ethiop. 2024, 38(3), 725-738. DOI: https://dx.doi.org/10.4314/bcse.v38i3.14

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铂(IV)、钌(III)和铱(III)茶碱络合物的合成、光谱和生物学特征

本研究采用微量分析、（傅立叶变换红外光谱、紫外可见光谱）光谱、磁性、热重、X 射线粉末衍射（XRD）图谱和透射电子显微镜（TEM）技术，对三种合成的茶碱（TPH）与钌（III）、铂（IV）和铱（III）金属离子的配合物进行了表征。经傅立叶变换红外光谱测量证实，上述金属离子通过氮原子位置 N7 上的去质子化 NH 基团与 TPH 药物螯合物配位成单齿配体。此外，还考察了复合物的导电性和磁感应强度。根据目前的数据，合成的配合物具有八面体几何结构。除了铱（III）配合物由于螯合球内存在一个氯原子而具有非电解性质外，其他配合物在二甲基亚砜溶液中的摩尔电导率都具有电解性质。生成的茶碱络合物的（金属：配体）配比为 1:2。TPH 复合物还针对 G（+）型细菌（枯草杆菌和金黄色葡萄球菌）和 G（-）型细菌（绿脓杆菌和大肠杆菌）进行了体外测试，以评估其抗菌功效。人类乳腺癌和肝癌细胞系被用来测试 TPH 复合物的体外抗癌特性。关键词：茶碱、金属离子、螯合、八面体、光谱分析、纳米颗粒、生物评价 Bull.Chem.Soc.2024, 38(3), 725-738. DOI: https://dx.doi.org/10.4314/bcse.v38i3.14

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来源期刊

Bulletin of the Chemical Society of Ethiopia 化学-化学综合

CiteScore

2.20

自引率

8.30%

发文量

113

审稿时长

6-12 weeks

期刊介绍： The Bulletin of the Chemical Society of Ethiopia (BCSE) is a triannual publication of the Chemical Society of Ethiopia. The BCSE is an open access and peer reviewed journal. The BCSE invites contributions in any field of basic and applied chemistry.