Effect of Solanum aculeastrum on hematological parameters of Al-bino mice infected with Aspergillus fumigatus

Bionatura Pub Date : 2024-03-15 DOI:10.21931/rb/2024.09.01.48

Sara Ghalib Allwi Al-Saffy, Dalia Abdalkareem Abdulshaheed

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Abstract

The goal of the current study was to research the changes in hematological parameters: WBC count, RBCs count, Hb, PCV, neutrophil, lymphocyte, and monocyte in albino mice infected with Aspergillus fumigatus by intraperitoneal injection after induced immunosuppression by intraperitoneal injection of cortisone. The current research also examined an attempt to reduce the infection load by treating Solanum aculeastrum. The result shows higher decreased significance (P≤0. 05) in RBCs, Hb, and PCV after being infected with A. fumigatus 7. 1 ± 0. 8, 11. 3 ± 0. 5 and 41. 5 ± 2. 4, respectively, while the total WBC count, neutrophil, lymphocyte, and monocytes were increased significantly (P≤0. 05) after treatment with S. aculeastrum in groups infected with A. fumigatus, compared to other groups. According to these results, we conclude that the alcoholic extract of S. Astrum has significant therapeutic and antifungal characteristics that lead to an increase in the total WBC count and, therefore, is considered a necessary alternative therapy for increasing immunity. Keywords: Cortisone, Hematology, Fungi, Iraq.

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茄属植物对感染曲霉菌的 Al-bino 小鼠血液学参数的影响

本研究的目的是研究血液学参数的变化：通过腹腔注射可的松诱导免疫抑制后，白化小鼠腹腔注射感染曲霉菌后，白细胞计数、红细胞计数、血红蛋白、PCV、中性粒细胞、淋巴细胞和单核细胞的变化。目前的研究还探讨了通过处理茄属植物来减少感染量的尝试。结果表明，感染烟曲霉菌后，RBC、Hb 和 PCV 的显著性降低（P≤0.1 ± 0. 8、11. 3 ± 0. 5 和 41.而与其他组相比，感染烟曲霉菌的组使用 S. aculeastrum 治疗后，白细胞总数、中性粒细胞、淋巴细胞和单核细胞显著增加（P≤0.根据这些结果，我们得出结论：S. Astrum 的酒精提取物具有明显的治疗和抗真菌特性，可导致白细胞总数的增加，因此被认为是增加免疫力的一种必要的替代疗法：可的松血液学真菌伊拉克

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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