Advances in Analytical Techniques and Therapeutic Applications of Phytochemicals

Chimezie O. Onukwuli, Chisom E. Izuchukwu, U. Paul-Chima
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Abstract

The attentiveness towards phytochemicals, which represents the group of biologically active compounds derived from plants, also referred to as phytocomponents, and has sprung up due to their therapeutics implications. This review article encourages researchers to appreciate the most recent innovations in analytical approaches to the determination and measurement of phytochemicals, methods such as spectroscopy, chromatography and mass spectrometry are some of the techniques examined here. Moreover, it covers the bioactivity and mechanisms of action of phytochemicals, the effect of which is their being directing to molecular targets and leading to a modulation of cellular signaling network. The way that the plant-derived compounds are absorbed, distributed, metabolized and excreted (pharmacokinetics) and the way that they act on the body (pharmacodynamics) are examined in details and they are found to be efficient for treating many diseases. Drug discovery and development also include a range of interdisciplinary fields such as chemistry, pharmacology, and other disciplines. In these areas, research includes also industry considerations and ethical practices. This overview covers the range of achievements based on phytochemical research in the current stage and the expectations on its prospective influence on health care. Keywords: Phytochemicals, Analytical Techniques, Bioactivity, Pharmacokinetics and Pharmacodynamics
植物化学物质的分析技术和治疗应用进展
植物化学物质是指从植物中提取的一组具有生物活性的化合物,也被称为植物成分,由于其治疗意义而备受关注。这篇综述文章鼓励研究人员了解测定和测量植物化学物质的分析方法的最新创新,其中包括光谱法、色谱法和质谱法等方法。此外,该书还介绍了植物化学物质的生物活性和作用机制,其作用是引导分子靶标,从而调节细胞信号网络。植物提取物的吸收、分布、代谢和排泄方式(药代动力学)以及它们对人体的作用方式(药效学)都会得到详细研究,并发现它们能有效治疗多种疾病。药物发现与开发还包括一系列跨学科领域,如化学、药理学和其他学科。在这些领域,研究还包括行业考虑因素和伦理实践。本综述介绍了现阶段植物化学研究取得的一系列成果,以及对其未来对医疗保健影响的预期。关键词植物化学物质、分析技术、生物活性、药代动力学和药效学
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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