Lack of causal association between cheese intake and risk of peripheral vascular diseases: A two-sample Mendelian randomization study

Medicine Advances Pub Date : 2024-03-20 DOI:10.1002/med4.48
Song Wen, Zehan Huang, Guodong He, Bin Zhang, Yuqing Huang
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Abstract

Background

Previous observational studies have yielded inconclusive findings regarding the potential association between cheese intake and peripheral vascular diseases (PVDs). We sought to systematically investigate the causal link between cheese intake and PVDs.

Methods

A two-sample Mendelian randomization (MR) investigation was undertaken to evaluate the causal link between cheese intake and PVDs. This MR analysis relied on summary statistics derived from published genome-wide associations studies (GWAS). GWAS summary statistics for cheese intake (N = 451,486), peripheral artery disease (PAD) (N = 361,194), PVD (N = 463,010), pulmonary embolism (PE) (N = 463,010), and deep vein thrombosis (DVT) (N = 6795) were derived from the UK Biobank. GWAS summary statistics for peripheral angiopathy (N = 162,394), aortic dissection (N = 218,792), aortic aneurysm (AA) (N = 218,792), other PVDs (N = 218,792), and arterial embolism and thrombosis of lower extremity artery (N = 218,792) were extracted from the FinnGen. Primary analysis was performed using an inverse variance weighted method. Sensitivity analyses included weighted median, MR Egger, and weighted mode analyses. Results are shown as odd ratio (OR) and 95% confidence interval (CI).

Results

Genetically predicted cheese intake was not associated with PAD (OR = 1.00, 95% CI: 1.00–1.00, p = 0.953), PVD (OR = 1.00, 95% CI: 0.99–1.00, p = 0.265), peripheral angiopathy (OR = 0.56, 95% CI: 0.09–3.66, p = 0.566), aortic dissection(OR = 0.69, 95% CI: 0.19–2.55, p = 0.583), AA(OR = 0.92, 95% CI: 0.46–1.82, p = 0.809), other PVDs (OR = 0.99, 95% CI: 0.44–2.21, p = 0.979), PE (OR = 1.00, 95% CI:1.00–1.00, p = 0.635), DVT (OR = 0.83, 95% CI: 0.62–1.12, p = 0.229), and arterial embolism and thrombosis of lower extremity artery (OR = 0.69, 95% CI: 0.21–2.29, p = 0.5413).

Conclusion

Based on the results of our two-sample MR analysis, we found no significant association between cheese intake and the risk of PVDs. We firmly believed that these findings had the potential to enhance the efficacy of prevention strategies for PVDs, at both the national and clinical level, by improving our understanding of the risk factors involved in their development. Low-sugar, low-salt and low-fat cheese may be a good choice for people at high risk of PVDs.

Abstract Image

奶酪摄入量与外周血管疾病风险之间缺乏因果关系:双样本孟德尔随机研究
以往的观察性研究对奶酪摄入量与外周血管疾病(PVDs)之间的潜在联系没有得出结论。为了评估奶酪摄入量与心血管疾病之间的因果关系,我们进行了一次双样本孟德尔随机化(MR)调查。这项MR分析依赖于从已发表的全基因组关联研究(GWAS)中得出的汇总统计数据。奶酪摄入量(N = 451,486 )、外周动脉疾病(PAD)(N = 361,194 )、心血管疾病(PVD)(N = 463,010 )、肺栓塞(PE)(N = 463,010 )和深静脉血栓形成(DVT)(N = 6795 )的 GWAS 概要统计数据来自英国生物库。外周血管病(162,394 人)、主动脉夹层(218,792 人)、主动脉瘤(AA)(218,792 人)、其他心血管内皮病变(218,792 人)以及下肢动脉栓塞和血栓形成(218,792 人)的 GWAS 概要统计数据来自 FinnGen。 主要分析采用反方差加权法。敏感性分析包括加权中位数、MR Egger 和加权模式分析。结果显示为奇数比(OR)和 95% 置信区间(CI)。基因预测的奶酪摄入量与 PAD(OR = 1.00,95% CI:1.00-1.00,p = 0.953)、PVD(OR = 1.00,95% CI:0.99-1.00,P = 0.265)、外周血管病(OR = 0.56,95% CI:0.09-3.66,P = 0.566)、主动脉夹层(OR = 0.69,95% CI:0.19-2.55,P = 0.583)、AA(OR = 0.92,95% CI:0.46-1.82,P = 0.809)、其他 PVDs(OR = 0.99,95% CI:0.44-2.21,P = 0.979)、PE(OR = 1.00,95% CI:1.00-1.00,P = 0.635)、DVT(OR = 0.83,95% CI:0.62-1.12,P = 0.229)和下肢动脉栓塞和血栓形成(OR = 0.根据我们的双样本 MR 分析结果,我们发现奶酪摄入量与心血管疾病风险之间没有显著关联。我们坚信,通过进一步了解心血管疾病发生的风险因素,这些发现有可能在国家和临床层面提高心血管疾病预防策略的有效性。低糖、低盐和低脂奶酪可能是心血管疾病高危人群的不错选择。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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