Secondary analysis: Graph analysis of brain connectivity network in autism spectrum disorder.

IF 1.5 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Journal of Research in Medical Sciences Pub Date : 2024-01-30 eCollection Date: 2024-01-01 DOI:10.4103/jrms.jrms_428_22

Fatemeh Pourmotahari, Nasrin Borumandnia, Seyyed Mohammad Tabatabaei, Hamid Alavimajd

{"title":"Secondary analysis: Graph analysis of brain connectivity network in autism spectrum disorder.","authors":"Fatemeh Pourmotahari, Nasrin Borumandnia, Seyyed Mohammad Tabatabaei, Hamid Alavimajd","doi":"10.4103/jrms.jrms_428_22","DOIUrl":null,"url":null,"abstract":"Background: Autism spectrum disorder is a neurodevelopmental condition in which impaired connectivity of the brain network. The functional magnetic resonance imaging (fMRI) technique can provide information on the early diagnosis of autism by evaluating communication patterns in the brain. The present study aimed to assess functional connectivity (FC) variations in autism patients.Materials and methods: Resting-state fMRI data were obtained from the \"ABIDE\" website. These data include 294 autism patients with a mean (standard deviation) age of 16.49 (7.63) and 312 healthy individuals with a mean (standard deviation) age of 15.98 (6.31). In this study, changes in communication patterns across different brain regions in autism patients were investigated using graph-based models.Results: The FC cluster of 17 regions in the brain, such as the hippocampus, cuneus, and inferior temporal, was different between the patient and healthy groups. Based on connectivity analysis of pair regions, 36 of the 136 correlations in the cluster were significantly different between the two groups. The middle temporal gyrus had more communication than the other regions. The largest difference between groups was - 0.112, which corresponding to the right middle temporal and right thalamus regions.Conclusion: The findings of this study revealed functional relationship alterations in patients with autism compared to healthy individuals, indicating the disease's effects on the brain connectivity network.","PeriodicalId":50062,"journal":{"name":"Journal of Research in Medical Sciences","volume":"29 ","pages":"2"},"PeriodicalIF":1.5000,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10956556/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Research in Medical Sciences","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4103/jrms.jrms_428_22","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Autism spectrum disorder is a neurodevelopmental condition in which impaired connectivity of the brain network. The functional magnetic resonance imaging (fMRI) technique can provide information on the early diagnosis of autism by evaluating communication patterns in the brain. The present study aimed to assess functional connectivity (FC) variations in autism patients.

Materials and methods: Resting-state fMRI data were obtained from the "ABIDE" website. These data include 294 autism patients with a mean (standard deviation) age of 16.49 (7.63) and 312 healthy individuals with a mean (standard deviation) age of 15.98 (6.31). In this study, changes in communication patterns across different brain regions in autism patients were investigated using graph-based models.

Results: The FC cluster of 17 regions in the brain, such as the hippocampus, cuneus, and inferior temporal, was different between the patient and healthy groups. Based on connectivity analysis of pair regions, 36 of the 136 correlations in the cluster were significantly different between the two groups. The middle temporal gyrus had more communication than the other regions. The largest difference between groups was - 0.112, which corresponding to the right middle temporal and right thalamus regions.

Conclusion: The findings of this study revealed functional relationship alterations in patients with autism compared to healthy individuals, indicating the disease's effects on the brain connectivity network.

查看原文本刊更多论文

二次分析：自闭症谱系障碍大脑连接网络图谱分析。

背景：自闭症谱系障碍是一种大脑网络连接受损的神经发育疾病。功能磁共振成像（fMRI）技术可通过评估大脑中的交流模式为自闭症的早期诊断提供信息。本研究旨在评估自闭症患者的功能连接（FC）变化：静息态 fMRI 数据来自 "ABIDE "网站。这些数据包括 294 名自闭症患者（平均（标准差）年龄为 16.49（7.63）岁）和 312 名健康人（平均（标准差）年龄为 15.98（6.31）岁）。本研究使用基于图的模型研究了自闭症患者不同脑区交流模式的变化：结果：自闭症患者与健康组的海马、楔形、下颞等17个脑区的FC群存在差异。根据对区域的连通性分析，在该集群的 136 个相关性中，有 36 个在两组之间存在显著差异。颞中回比其他区域有更多的交流。组间最大差异为-0.112，对应于右侧颞中部和右侧丘脑区域：本研究结果显示，与健康人相比，自闭症患者的功能关系发生了改变，这表明自闭症对大脑连接网络产生了影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Research in Medical Sciences MEDICINE, GENERAL & INTERNAL-

CiteScore

2.60

自引率

6.20%

发文量

审稿时长

3-6 weeks

期刊介绍： Journal of Research in Medical Sciences, a publication of Isfahan University of Medical Sciences, is a peer-reviewed online continuous journal with print on demand compilation of issues published. The journal’s full text is available online at http://www.jmsjournal.net. The journal allows free access (Open Access) to its contents and permits authors to self-archive final accepted version of the articles on any OAI-compliant institutional / subject-based repository.