Depot-medroxyprogesterone acetate: Lipid profile changes and associated cardiovascular risks among acceptors in Sagamu, South West Nigeria.

IF 0.6 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Journal of Public Health in Africa Pub Date : 2024-03-01 eCollection Date: 2023-11-30 DOI:10.4081/jphia.2023.1664

Oluwaseyi Odelola, Adebayo Akadri

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Abstract

Depot-medroxyprogesterone acetate (DMPA) is a highly effective long acting reversible contraceptive. Alterations in lipid profile have been associated with use of DMPA, however there is considerable debate about how profound these effects are. Hence the aim of this study is to determine the effect of DMPA on lipid profile and the associated cardiovascular risks. This was a prospective longitudinal study conducted at the family planning clinic of Olabisi Onabanjo University Teaching Hospital Sagamu, Ogun State. Sixty eight new acceptors of DMPA who had their blood samples collected for lipid profile assays at initiation of DMPA, and then at 3 months and 6 months. Data were analyzed using SPSS version 24. After 3 months of DMPA use, there was statistically significant increase in serum Total Cholesterol (TC) concentration (P=0.022), serum Low Density Lipoprotein (LDL) concentration (P=0.033), non significant increase in serum Triglyceride (TG) concentration (P=0.150) and non-significant decrease in serum Higher Density Lipoprotein (HDL) concentration (P=0.076). However, after 6 months of DMPA use, there was statistically significant increase in serum TC concentration (P=0.002), serum LDL concentration (P=0.003), serum TG concentration (P=0.001) and significant decrease in serum HDL concentration (P=0.001). DMPA use is associated with increased serum TC, TG, LDL, and reduction in HDL after 6 months of use. These changes in lipid profile may increase the risk of cardiovascular diseases.

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醋酸去甲羟孕酮：尼日利亚西南部萨加穆接受者的血脂变化和相关心血管风险。

醋酸去羟孕酮（DMPA）是一种高效的长效可逆避孕药。血脂状况的改变与使用 DMPA 有关，但对于这些影响的深远程度还存在相当大的争议。因此，本研究旨在确定 DMPA 对血脂状况的影响以及相关的心血管风险。这是一项前瞻性纵向研究，在奥贡州奥拉比西-奥纳班霍大学萨加穆教学医院的计划生育诊所进行。68 名新接受 DMPA 的患者在开始使用 DMPA 时、3 个月后和 6 个月后被采集血样进行血脂分析。数据使用 SPSS 24 版进行分析。使用 DMPA 3 个月后，血清总胆固醇（TC）浓度（P=0.022）、血清低密度脂蛋白（LDL）浓度（P=0.033）有统计学意义的显著上升，血清甘油三酯（TG）浓度（P=0.150）无显著上升，血清高密度脂蛋白（HDL）浓度（P=0.076）无显著下降。然而，使用 DMPA 6 个月后，血清 TC 浓度（P=0.002）、血清 LDL 浓度（P=0.003）、血清 TG 浓度（P=0.001）均有统计学意义的显著增加，而血清 HDL 浓度则显著下降（P=0.001）。使用 DMPA 6 个月后，血清 TC、TG、LDL 增高，HDL 降低。这些血脂变化可能会增加罹患心血管疾病的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Public Health in Africa PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

自引率

0.00%

发文量

审稿时长

10 weeks

期刊介绍： The Journal of Public Health in Africa (JPHiA) is a peer-reviewed, academic journal that focuses on health issues in the African continent. The journal editors seek high quality original articles on public health related issues, reviews, comments and more. The aim of the journal is to move public health discourse from the background to the forefront. The success of Africa’s struggle against disease depends on public health approaches.