Barriers toward xenotransplantation in Arab World.

IF 3.3 4区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
Maya Ghazi, Aalaa Saleh, Malak Abdallah, Diala El Masri, Jad El Masri, Lemir Majed El Ayoubi, Jihad Hawi, Abdo Jurjus
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引用次数: 0

Abstract

Organ transplant is a crucial therapeutic strategy offering a life-saving and transformative medical intervention. It provides an opportunity to improve their quality of life and increase their lifespan. The shortage of organs remains a critical global challenge, leading to a prolonged waiting times for organ receivers, which contributes to an increase in morbidity and mortality rates. Hence, xenotransplantation offered a promising solution to the global shortage of organs through the use of animal organs, leading to an increase in donor availability, reducing waiting times, minimizing organ trafficking, improving genetic engineering advancements, and driving scientific innovation. Even though xenotransplantation has many benefits in the clinical setting, it has many barriers that are hindering its achievements and constraining its occurrence. Some barriers to xenotransplant are general, such as the immunological barrier, while others are specific to certain regions due to local causes. The Arab region exhibits disparities in clinical settings compared to the global context, marked by the huge economic crisis and a shortage of trained healthcare professionals. Considering the huge resources and advancements needed in the field of xenotransplantation, this review aims to explore the specific barriers toward xenotransplantation in the Arab countries, highlighting the challenges to overcome these barriers.

阿拉伯世界异种移植的障碍。
器官移植是一项重要的治疗策略,是挽救生命和改变生活的医疗干预措施。它为改善患者的生活质量和延长其寿命提供了机会。器官短缺仍然是一个严峻的全球性挑战,导致器官接受者的等待时间延长,从而导致发病率和死亡率上升。因此,异种器官移植通过使用动物器官,为解决全球器官短缺问题提供了一个前景广阔的解决方案,从而增加了供体的可用性,缩短了等待时间,最大限度地减少了器官贩运,提高了基因工程的进步,并推动了科学创新。尽管异种器官移植在临床上有许多益处,但它也有许多障碍,阻碍了它的成就,限制了它的发生。异种器官移植的一些障碍是普遍性的,如免疫障碍,而另一些障碍则是某些地区因当地原因而特有的。阿拉伯地区的临床环境与全球相比存在差距,其特点是巨大的经济危机和训练有素的医疗专业人员短缺。考虑到异种移植领域所需的巨大资源和进步,本综述旨在探讨阿拉伯国家异种移植的具体障碍,并强调克服这些障碍所面临的挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Xenotransplantation
Xenotransplantation 医学-医学:研究与实验
CiteScore
6.80
自引率
15.40%
发文量
58
审稿时长
>12 weeks
期刊介绍: Xenotransplantation provides its readership with rapid communication of new findings in the field of organ and tissue transplantation across species barriers.The journal is not only of interest to those whose primary area is xenotransplantation, but also to veterinarians, microbiologists and geneticists. It also investigates and reports on the controversial theological, ethical, legal and psychological implications of xenotransplantation.
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