Application of membrane separation technology in the purification of pharmaceutical components.

IF 2 4区生物学 Q3 BIOCHEMICAL RESEARCH METHODS

Preparative Biochemistry & Biotechnology Pub Date : 2024-10-01 Epub Date: 2024-03-25 DOI:10.1080/10826068.2024.2328673

Yun Bi, Jingyi Dong, Yujia Zhou, Manyue Zhang, Xingying Chen, Yuyan Zhang

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Abstract

Traditional Chinese medicine (TCM) is often composed of a variety of natural medicines. Its composition is complex, and many of its components can not be analyzed and identified. The first step in the rational application of TCM is to successfully separate the effective components which is also a great inspiration for the development of new drugs. Among the many separation technologies of TCM, the traditional heating concentration separation technology has high energy consumption and low efficiency. As a new separation technology, membrane separation technology has the characteristics of simple operation, high efficiency, environment-friendly and so on. The separation effect of high molecular weight difference solution is better. The applications of several main membrane separation technologies such as microfiltration, nanofiltration, ultrafiltration and reverse osmosis are reviewed, the methods of restoring membrane flux after membrane fouling are discussed, and their large-scale industrial applications in the future are prospected and summarized.

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膜分离技术在药物成分纯化中的应用。

中国传统医药通常由多种天然药物组成。其成分复杂，许多成分无法分析和鉴定。成功分离中药的有效成分是合理应用中药的第一步，也是开发新药的重要启示。在众多中药分离技术中，传统的加热浓缩分离技术能耗高、效率低。膜分离技术作为一种新型分离技术，具有操作简单、效率高、环境友好等特点。高分子量差溶液的分离效果更好。综述了微滤、纳滤、超滤和反渗透等几种主要膜分离技术的应用，探讨了膜堵塞后恢复膜通量的方法，并对其未来大规模工业应用进行了展望和总结。

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来源期刊

Preparative Biochemistry & Biotechnology 工程技术-生化研究方法

CiteScore

4.90

自引率

3.40%

发文量

审稿时长

2 months

期刊介绍： Preparative Biochemistry & Biotechnology is an international forum for rapid dissemination of high quality research results dealing with all aspects of preparative techniques in biochemistry, biotechnology and other life science disciplines.