Trends in the Synthesis of Antimicrobial Derivatives by using the Gewald, Strecker, and Groebke-Blackburn-Bienaymé (GBB) Reactions.

IF 1.9 4区医学 Q3 CHEMISTRY, MEDICINAL

Medicinal Chemistry Pub Date : 2024-01-01 DOI:10.2174/0115734064282699240315042428

Kaushal Naithani, Subhendu Bhowmik

{"title":"Trends in the Synthesis of Antimicrobial Derivatives by using the Gewald, Strecker, and Groebke-Blackburn-Bienaymé (GBB) Reactions.","authors":"Kaushal Naithani, Subhendu Bhowmik","doi":"10.2174/0115734064282699240315042428","DOIUrl":null,"url":null,"abstract":"Background: Multicomponent reactions are highly useful in synthesizing natural products and bioactive molecules. Out of several MCRs, although utilized widely, some remain neglected in review articles. The Gewald and Groebke-Blackburn-Bienaymé (GBB) reactions are two such reactions. This comprehensive review assimilates applications of Gewald and Groebke-Blackburn- Bienayme reactions in synthesizing novel antimicrobial agents. It presents the antimicrobial properties of the synthesized molecules, providing an overview of their potential druggability.Objective: Developing novel antimicrobial agents is the need of the hour. Toward this objective, the scientific community is developing new methods for constructing novel architectures with potential antimicrobial properties. This review will showcase the usefulness of the Gewald, Strecker, and Groebke-Blackburn-Bienaymé (GBB) reactions in synthesizing antimicrobial molecules.Methods: The articles are searched by using the Sci-finder search tool and summarize the chemistry of their synthesis and antimicrobial evaluation of the molecules.Results: This review focuses on synthesizing antimicrobial molecules using the Gewald, Strecker, and Groebke-Blackburn-Bienaymé (GBB) reactions. The antimicrobial activities of the synthesized molecules are also summarized in tables.Conclusion: This review will briefly overview the application of the Gewald, Strecker, and Groebke- Blackburn-Bienaymé (GBB) reactions in synthesizing novel antimicrobial molecules. It contains several molecules with promising activity against resistant and non-resistant microbial strains. These promising molecules could be studied further to develop novel antibiotics.","PeriodicalId":18382,"journal":{"name":"Medicinal Chemistry","volume":" ","pages":"663-688"},"PeriodicalIF":1.9000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medicinal Chemistry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2174/0115734064282699240315042428","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Multicomponent reactions are highly useful in synthesizing natural products and bioactive molecules. Out of several MCRs, although utilized widely, some remain neglected in review articles. The Gewald and Groebke-Blackburn-Bienaymé (GBB) reactions are two such reactions. This comprehensive review assimilates applications of Gewald and Groebke-Blackburn- Bienayme reactions in synthesizing novel antimicrobial agents. It presents the antimicrobial properties of the synthesized molecules, providing an overview of their potential druggability.

Objective: Developing novel antimicrobial agents is the need of the hour. Toward this objective, the scientific community is developing new methods for constructing novel architectures with potential antimicrobial properties. This review will showcase the usefulness of the Gewald, Strecker, and Groebke-Blackburn-Bienaymé (GBB) reactions in synthesizing antimicrobial molecules.

Methods: The articles are searched by using the Sci-finder search tool and summarize the chemistry of their synthesis and antimicrobial evaluation of the molecules.

Results: This review focuses on synthesizing antimicrobial molecules using the Gewald, Strecker, and Groebke-Blackburn-Bienaymé (GBB) reactions. The antimicrobial activities of the synthesized molecules are also summarized in tables.

Conclusion: This review will briefly overview the application of the Gewald, Strecker, and Groebke- Blackburn-Bienaymé (GBB) reactions in synthesizing novel antimicrobial molecules. It contains several molecules with promising activity against resistant and non-resistant microbial strains. These promising molecules could be studied further to develop novel antibiotics.

查看原文本刊更多论文

利用 Gewald、Strecker 和 Groebke-Blackburn-Bienaymé (GBB) 反应合成抗菌剂衍生物的趋势。

背景：多组分反应在合成天然产物和生物活性分子方面非常有用。在几种多组分反应中，虽然应用广泛，但有些反应在综述文章中仍被忽视。Gewald 反应和 Groebke-Blackburn-Bienaymé (GBB) 反应就是其中的两种。这篇综述吸收了 Gewald 和 Groebke-Blackburn-Bienayme 反应在合成新型抗菌剂中的应用。文章介绍了合成分子的抗菌特性，概述了其潜在的可药用性：开发新型抗菌剂是当务之急。为实现这一目标，科学界正在开发构建具有潜在抗菌特性的新型结构的新方法。本综述将展示 Gewald、Strecker 和 Groebke-Blackburn-Bienaymé (GBB) 反应在合成抗菌分子中的作用：方法：使用 Sci-finder 搜索工具搜索文章，总结其合成化学过程和分子的抗菌评估结果：这篇综述的重点是利用 Gewald、Strecker 和 Groebke-Blackburn-Bienaymé（GBB）反应合成抗菌分子。结论：本综述将简要概述 Gewald、Strecker 和 Groebke- Blackburn-Bienaymé (GBB) 反应在合成新型抗菌分子中的应用。它包含几种对耐药性和非耐药性微生物菌株具有良好活性的分子。可以进一步研究这些有前景的分子，以开发新型抗生素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Medicinal Chemistry 医学-医药化学

CiteScore

4.30

自引率

4.30%

发文量

109

审稿时长

12 months

期刊介绍： Aims & Scope Medicinal Chemistry a peer-reviewed journal, aims to cover all the latest outstanding developments in medicinal chemistry and rational drug design. The journal publishes original research, mini-review articles and guest edited thematic issues covering recent research and developments in the field. Articles are published rapidly by taking full advantage of Internet technology for both the submission and peer review of manuscripts. Medicinal Chemistry is an essential journal for all involved in drug design and discovery.