Associations of urinary volatile organic compounds with cardiovascular disease among the general adult population.

IF 2.2 4区医学 Q3 ENVIRONMENTAL SCIENCES

International Journal of Environmental Health Research Pub Date : 2024-11-01 Epub Date: 2024-03-24 DOI:10.1080/09603123.2024.2331732

Meijuan Ma, Xu Zhu, Feipeng Li, Gongchang Guan, Rutai Hui, Ling Zhu, Hui Pang, Yong Zhang

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引用次数: 0

Abstract

This study was to estimate the associations of volatile organic compounds (VOCs) exposure with the prevalence of total and specific cardiovascular disease (CVD) among the general adult population. This cross-sectional study analyzed 15 urinary VOC metabolites in the general population using the 2011-2016 National Health and Nutrition Examination Survey (n = 5,213). The weighted study population with 47.0 years median age, was primarily female (51.2%). The prevalence of total CVD in the overall population was 7.9%. The single-exposure analyzes of AAMA, ATCA, CEMA, CYMA, DHBMA, 3HPMA, and 3MHA +4MHA were significantly associated with increased prevalence of total CVD. Qgcomp regression consistently showed that urinary VOCs-mixed exposure was positively correlated with the prevalence of total and specific CVDs (chronic heart failure, angina, and stroke), and highlighted each VOCs metabolite weights and direction. The similar results were observed for the WQS regression using mixed analysis methods. In conclusion, exposure to VOCs increases CVD prevalence and advances the identification of risk factors for CVD for environmental study.

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普通成年人尿液中挥发性有机化合物与心血管疾病的关系。

本研究旨在估算普通成年人群中挥发性有机化合物（VOC）暴露与总心血管疾病（CVD）和特定心血管疾病（CVD）患病率之间的关系。这项横断面研究利用 2011-2016 年全国健康与营养调查（n = 5,213 人）分析了普通人群尿液中的 15 种挥发性有机化合物代谢物。加权研究人群的中位年龄为 47.0 岁，主要为女性（51.2%）。总体心血管疾病患病率为 7.9%。AAMA、ATCA、CEMA、CYMA、DHBMA、3HPMA 和 3MHA +4MHA 的单次暴露分析与总心血管疾病患病率的增加显著相关。Qgcomp 回归一致表明，尿液中的混合挥发性有机化合物暴露量与总心血管疾病和特定心血管疾病（慢性心力衰竭、心绞痛和中风）的发病率呈正相关，并突出了每种挥发性有机化合物代谢物的权重和方向。在使用混合分析方法进行 WQS 回归时也观察到了类似的结果。总之，暴露于挥发性有机化合物会增加心血管疾病的发病率，并推动了环境研究对心血管疾病风险因素的识别。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Environmental Health Research 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.70

自引率

3.10%

发文量

134

审稿时长

>12 weeks

期刊介绍： International Journal of Environmental Health Research ( IJEHR ) is devoted to the rapid publication of research in environmental health, acting as a link between the diverse research communities and practitioners in environmental health. Published articles encompass original research papers, technical notes and review articles. IJEHR publishes articles on all aspects of the interaction between the environment and human health. This interaction can broadly be divided into three areas: the natural environment and health – health implications and monitoring of air, water and soil pollutants and pollution and health improvements and air, water and soil quality standards; the built environment and health – occupational health and safety, exposure limits, monitoring and control of pollutants in the workplace, and standards of health; and communicable diseases – disease spread, control and prevention, food hygiene and control, and health aspects of rodents and insects. IJEHR is published in association with the International Federation of Environmental Health and includes news from the Federation of international meetings, courses and environmental health issues.