Metastatic colorectal cancer- third line therapy and beyond.

IF 2.9 3区医学 Q2 ONCOLOGY

Expert Review of Anticancer Therapy Pub Date : 2024-05-01 Epub Date: 2024-04-03 DOI:10.1080/14737140.2024.2334784

Tiffany Foo, Amitesh Roy, Christos Karapetis, Amanda Townsend, Timothy Price

引用次数: 0

Abstract

Introduction: The outcome of patients with metastatic colorectal cancer (mCRC) has improved significantly in the last few decades. Metastatic colorectal cancer is a highly heterogenous cancer. Beyond second line chemotherapy, treatment decisions are often based on molecular testing.

Method: In this narrative review, we provide a comprehensive summary of data from key clinical trials and discuss how to integrate these agents into the current treatment landscape of metastatic colorectal cancer.

Expert opinion: In the era of precision medicine, molecular testing plays an increasingly important role in the management of mCRC. Efforts need to be made to target treatment based on molecular test results.

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转移性结直肠癌--三线治疗及以后。

简介过去几十年来，转移性结直肠癌（mCRC）患者的预后有了显著改善。转移性结直肠癌是一种高度异质性癌症。除二线化疗外，治疗决策通常基于分子检测：在这篇叙述性综述中，我们全面总结了主要临床试验的数据，并讨论了如何将这些药物纳入当前转移性结直肠癌的治疗方案：在精准医疗时代，分子检测在转移性结直肠癌的治疗中发挥着越来越重要的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Review of Anticancer Therapy 医学-肿瘤学

CiteScore

5.10

自引率

3.00%

发文量

100

审稿时长

4-8 weeks

期刊介绍： Expert Review of Anticancer Therapy (ISSN 1473-7140) provides expert appraisal and commentary on the major trends in cancer care and highlights the performance of new therapeutic and diagnostic approaches. Coverage includes tumor management, novel medicines, anticancer agents and chemotherapy, biological therapy, cancer vaccines, therapeutic indications, biomarkers and diagnostics, and treatment guidelines. All articles are subject to rigorous peer-review, and the journal makes an essential contribution to decision-making in cancer care. Comprehensive coverage in each review is complemented by the unique Expert Review format and includes the following sections: Expert Opinion - a personal view of the data presented in the article, a discussion on the developments that are likely to be important in the future, and the avenues of research likely to become exciting as further studies yield more detailed results Article Highlights – an executive summary of the author’s most critical points.