Evaluation of the anticarcinogenic effects of Rutin on brain tissue in mice with Ehrlich ascites carcinoma by micro-computed tomography and histological methods.

IF 1.4 4区 医学 Q4 ONCOLOGY
Mert Ocak, Şükrü Ateş, Selda Kahveci, Aslı Okan, Züleyha Doğanyiğit, Sümeyye Uçar, Seher Yılmaz
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Abstract

Background: Studies for new treatment strategies on cancer continue, and new searches continue in the diagnosis and evaluation of cancer. This study examined the possible anticarcinogenic effect of Rutin on the brain tissues of male mice with Ehrlich ascites carcinoma (EAC).

Material and methods: We used micro-computed tomography (micro-CT) and histologically Hematoxylin&Eosin (H&E) staining methods for evaluation.

Results: In the evaluation results, we saw a significant decrease in the brain volume of the tumor group to the control group. The difference in volume between the Rutin treatment group and the control group was not significant. In the brain tissues of the tumor group, numerous degenerated neurons characterized by pericellular/perivascular space expansion, cell swelling, or expansion were detected in the cortex and hippocampus regions. We showed a reduction in the damage rate in the Rutin treated group.

Conclusion: As a result, Rutin was found to have an anticarcinogenic effect. In addition to the classical histological evaluation, we used a newer method, micro-CT, in our study. We believe that this study has important results both in terms of its originality and adding new information to the literature.

Abstract Image

用微型计算机断层扫描和组织学方法评估芦丁对艾氏腹水癌小鼠脑组织的抗癌作用。
背景:对癌症新治疗策略的研究仍在继续,对癌症诊断和评估的新探索也在继续。本研究探讨了芦丁对艾氏腹水癌(EAC)雄性小鼠脑组织可能的抗癌作用:材料: 我们使用微型计算机断层扫描(micro-CT)和组织学上的血红素和伊红(H&E)染色法进行评估:在评估结果中,我们发现肿瘤组的脑容量比对照组明显减少。芦丁治疗组与对照组的体积差异不明显。在肿瘤组的脑组织中,我们在大脑皮层和海马区发现了大量退化的神经元,其特征是细胞周/血管周间隙扩大、细胞肿胀或扩张。我们发现芦丁治疗组的损伤率有所下降:结论:芦丁具有抗癌作用。除了经典的组织学评估外,我们在研究中还使用了一种较新的方法--显微 CT。我们认为,这项研究在原创性和为文献增添新信息方面都取得了重要成果。
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来源期刊
CiteScore
3.40
自引率
0.00%
发文量
175
审稿时长
6-12 weeks
期刊介绍: Asia–Pacific Journal of Clinical Oncology is a multidisciplinary journal of oncology that aims to be a forum for facilitating collaboration and exchanging information on what is happening in different countries of the Asia–Pacific region in relation to cancer treatment and care. The Journal is ideally positioned to receive publications that deal with diversity in cancer behavior, management and outcome related to ethnic, cultural, economic and other differences between populations. In addition to original articles, the Journal publishes reviews, editorials, letters to the Editor and short communications. Case reports are generally not considered for publication, only exceptional papers in which Editors find extraordinary oncological value may be considered for review. The Journal encourages clinical studies, particularly prospectively designed clinical trials.
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