Perfluoroalkyl and polyfluoroalkyl substances and Cancer risk: results from a dose-response Meta-analysis

IF 3 4区环境科学与生态学 Q3 ENGINEERING, ENVIRONMENTAL

Journal of Environmental Health Science and Engineering Pub Date : 2024-03-21 DOI:10.1007/s40201-024-00899-w

Jingxuan Yang, Kui Zhang, Jingyi Shi, Zhuo Li, Hao Dai, Wenxing Yang

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引用次数: 0

Abstract

Background

Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are persistent organic pollutants in the environment. While some studies suggest that PFASs may contribute to cancer development, the link between PFAS exposure and cancer risk remains debated.

Methods

This dose-response meta-analysis explores the relationship between PFASs and cancer. It employs odds ratio (OR) and standardized mean difference (SMD), along with their 95% confidence interval (CI), to assess the effects of PFASs on cancer risk. Relevant studies were sourced from Web of Science, PubMed, Embase, Medline, and CNKI databases. The dose-response relationship was assessed by the fixed-effects model and least-squares regression.

Results

Forty studies, involving a total of 748,188 participants, were included in this meta-analysis. Out of these, 13 studies were specifically analyzed for the dose-response relationship. Findings revealed that exposure to PFASs, especially PFDA, significantly raises the risk of genitourinary cancers, and PFDA exposure shows a dose-dependent increase in overall and breast cancer risk. Additionally, PFOS exposure is associated with an increased cancer risk, and elevated PFOA levels were significantly observed in breast cancer patients.

Conclusions

The findings suggest that PFAS exposure is a potential cancer risk factor, with the carcinogenic potential of PFDA being dose-dependent.

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全氟烷基和多氟烷基物质与癌症风险："确实反应 "元分析的结果

摘要背景全氟烷基和多氟烷基物质（PFAS）是环境中的持久性有机污染物。虽然一些研究表明 PFAS 可能会导致癌症的发生，但 PFAS 暴露与癌症风险之间的联系仍存在争议。方法本剂量反应荟萃分析探讨了 PFAS 与癌症之间的关系。它采用几率比（OR）和标准化平均差（SMD）及其 95% 置信区间（CI）来评估 PFAS 对癌症风险的影响。相关研究来自 Web of Science、PubMed、Embase、Medline 和 CNKI 数据库。剂量-反应关系采用固定效应模型和最小二乘回归法进行评估。结果本次荟萃分析共纳入 40 项研究，涉及 748,188 名参与者。其中 13 项研究专门分析了剂量-反应关系。研究结果表明，暴露于全氟辛烷磺酸，尤其是全氟辛烷磺酸，会显著增加泌尿生殖系统癌症的风险，而暴露于全氟辛烷磺酸则会增加罹患总体癌症和乳腺癌的风险。此外，接触全氟辛烷磺酸也与癌症风险增加有关，在乳腺癌患者中明显观察到全氟辛酸水平升高。结论研究结果表明，接触全氟辛烷磺酸是一种潜在的癌症风险因素，其中全氟辛烷磺酸的致癌潜力与剂量有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Environmental Health Science and Engineering ENGINEERING, ENVIRONMENTAL-ENVIRONMENTAL SCIENCES

CiteScore

7.50

自引率

2.90%

发文量

期刊介绍： Journal of Environmental Health Science & Engineering is a peer-reviewed journal presenting timely research on all aspects of environmental health science, engineering and management. A broad outline of the journal''s scope includes: -Water pollution and treatment -Wastewater treatment and reuse -Air control -Soil remediation -Noise and radiation control -Environmental biotechnology and nanotechnology -Food safety and hygiene