Green Approach: Characterization, Antibacterial, Antitumor and Detoxification Potentials of Exopolysaccharides-Mediated Silver Nanoparticles Produced by Penicillium citrinum AUMC 11627

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-03-22 DOI:10.1134/s0026261723601525

M. M. Housseiny, E. M. Fawzy, M. A. Abu-Tahon, W. E. Abdallah, O. M. El-Mahdy

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Abstract

Developing a green effective approach and a suitable applicative process for increasing the efficiency of microbial nanomaterial synthesis is an emerging prospect for future industrial production. This was accomplished by employing exopolysaccharides (EPS) to obtain potent silver nanoparticles using Penicillium citrinum (EPS−AgNPs) as a reducing and stabilizing agent. EPS−AgNPs were analyzed by UV–Vis spectrophotometry, which showed a peak of absorbance at 420 nm. TEM was used to determine the morphology of the EPS−AgNPs and showed that the particles were 14.4 nm in size, well dispersed, and spherical. The stabilization of (EPS−AgNPs) was caused by amides and amines groups, which were confirmed via Fourier transform infrared. Moreover, the EPS−AgNPs showed excellent antibacterial activities against various human pathogenic bacterial strains in comparison to the potent antibiotics. Additionally, EPS−AgNPs were examined for their anticancer properties. Furthermore, EPS−AgNPs had a significant impact on the ochratoxin production. Finally, our findings confirm the benefits of adopting a bio green technique for the synthesis of antibacterial and detoxifying nanoparticles, which are predicted to provide new pathways for various cancers and infectious microbial diseases treatment.

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绿色方法：柠檬青霉 AUMC 11627 产生的外多糖介导的银纳米粒子的特性、抗菌、抗肿瘤和解毒潜力

摘要开发一种绿色有效的方法和合适的应用工艺，以提高微生物纳米材料合成的效率，是未来工业生产的一个新兴前景。本研究以柠檬青霉为还原剂和稳定剂，利用外多糖（EPS）获得强效银纳米粒子（EPS-AgNPs）。用紫外可见分光光度法对 EPS-AgNPs 进行分析，结果表明在 420 纳米处出现吸光峰。利用 TEM 确定了 EPS-AgNPs 的形态，结果表明其颗粒大小为 14.4 nm，分散良好，呈球形。EPS-AgNPs 的稳定是由酰胺和胺基团引起的，这一点已通过傅立叶变换红外光谱得到证实。此外，与强效抗生素相比，EPS-AgNPs 对多种人类致病细菌菌株具有出色的抗菌活性。此外，还研究了 EPS-AgNPs 的抗癌特性。此外，EPS-AgNPs 对赭曲霉毒素的产生也有显著影响。最后，我们的研究结果证实了采用生物绿色技术合成抗菌和解毒纳米粒子的益处，预计这将为各种癌症和传染性微生物疾病的治疗提供新的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.