HCC genomic landscape in Chinese individuals

IF 45.9 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-03-22 DOI:10.1038/s41575-024-00924-1

Eleni Kotsiliti

引用次数: 0

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中国人的 HCC 基因组状况

中国肝癌图谱项目的研究人员对494名未接受术前抗癌治疗的中国人（86.4%为男性，13.6%为女性）的肝细胞癌（HCC）肿瘤进行了深度全基因组测序。根据流行病学数据，94.5%的入组患者患有乙型肝炎，2.6%患有丙型肝炎，26.7%饮酒，36.8%吸烟。研究人员发现了23个候选编码驱动因子，其中6个是以前未曾描述过的（如FGA、HNF1A和PRDM11）。他们还发现了 31 个非编码驱动因子，其中 28 个以前未被描述。FGA也被描述为候选非编码（3′UTR）驱动因子，体外和体内实验表明它能调控HCC的进展和转移。此外，10个候选驱动因子（2个编码和8个非编码）的突变表现出明显的克隆富集。研究人员发现了 5 个以前未曾描述过的突变特征，包括新的单碱基置换特征 SBS_H8。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Gastroenterology &Hepatology 医学-胃肠肝病学

CiteScore

52.30

自引率

0.60%

发文量

147

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Gastroenterology & Hepatology aims to serve as the leading resource for Reviews and commentaries within the scientific and medical communities it caters to. The journal strives to maintain authority, accessibility, and clarity in its published articles, which are complemented by easily understandable figures, tables, and other display items. Dedicated to providing exceptional service to authors, referees, and readers, the editorial team works diligently to maximize the usefulness and impact of each publication. The journal encompasses a wide range of content types, including Research Highlights, News & Views, Comments, Reviews, Perspectives, and Consensus Statements, all pertinent to gastroenterologists and hepatologists. With its broad scope, Nature Reviews Gastroenterology & Hepatology ensures that its articles reach a diverse audience, aiming for the widest possible dissemination of valuable information. Nature Reviews Gastroenterology & Hepatology is part of the Nature Reviews portfolio of journals.