An inexpensive UV-LED photoacoustic based real-time sensor-system detecting exhaled trace-acetone

IF 7.1 1区医学 Q1 ENGINEERING, BIOMEDICAL

Photoacoustics Pub Date : 2024-03-21 DOI:10.1016/j.pacs.2024.100604

Jonas Pangerl , Pritam Sukul , Thomas Rück , Patricia Fuchs , Stefan Weigl , Wolfram Miekisch , Rudolf Bierl , Frank-Michael Matysik

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Abstract

In this research we present a low-cost system for breath acetone analysis based on UV-LED photoacoustic spectroscopy. We considered the end-tidal phase of exhalation, which represents the systemic concentrations of volatile organic compounds (VOCs) – providing clinically relevant information about the human health. This is achieved via the development of a CO₂-triggered breath sampling system, which collected alveolar breath over several minutes in sterile and inert containers. A real-time mass spectrometer is coupled to serve as a reference device for calibration measurements and subsequent breath analysis. The new sensor system provided a 3σ detection limit of 8.3 ppbV and an NNEA of 1.4E-9 Wcm⁻¹Hz^−0.5. In terms of the performed breath analysis measurements, 12 out of 13 fell within the error margin of the photoacoustic measurement system, demonstrating the reliability of the measurements in the field.

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基于 UV-LED 光声技术的廉价实时传感器系统检测呼出的痕量丙酮

在这项研究中，我们提出了一种基于紫外-LED 光声光谱的低成本呼气丙酮分析系统。我们考虑了呼气的潮气末阶段，该阶段代表了挥发性有机化合物 (VOC) 的系统浓度，可提供有关人体健康的临床相关信息。这是通过开发二氧化碳触发的呼气采样系统实现的，该系统在无菌惰性容器中收集肺泡呼气达数分钟之久。实时质谱仪可作为校准测量和后续呼气分析的参考装置。新传感器系统的 3σ 检测限为 8.3 ppbV，NNEA 为 1.4E-9Wcm-1Hz-0.5。在进行的呼气分析测量中，13 次测量中有 12 次在光声测量系统的误差范围内，这表明了现场测量的可靠性。

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来源期刊

Photoacoustics Physics and Astronomy-Atomic and Molecular Physics, and Optics

CiteScore

11.40

自引率

16.50%

发文量

审稿时长

53 days

期刊介绍： The open access Photoacoustics journal (PACS) aims to publish original research and review contributions in the field of photoacoustics-optoacoustics-thermoacoustics. This field utilizes acoustical and ultrasonic phenomena excited by electromagnetic radiation for the detection, visualization, and characterization of various materials and biological tissues, including living organisms. Recent advancements in laser technologies, ultrasound detection approaches, inverse theory, and fast reconstruction algorithms have greatly supported the rapid progress in this field. The unique contrast provided by molecular absorption in photoacoustic-optoacoustic-thermoacoustic methods has allowed for addressing unmet biological and medical needs such as pre-clinical research, clinical imaging of vasculature, tissue and disease physiology, drug efficacy, surgery guidance, and therapy monitoring. Applications of this field encompass a wide range of medical imaging and sensing applications, including cancer, vascular diseases, brain neurophysiology, ophthalmology, and diabetes. Moreover, photoacoustics-optoacoustics-thermoacoustics is a multidisciplinary field, with contributions from chemistry and nanotechnology, where novel materials such as biodegradable nanoparticles, organic dyes, targeted agents, theranostic probes, and genetically expressed markers are being actively developed. These advanced materials have significantly improved the signal-to-noise ratio and tissue contrast in photoacoustic methods.