The contribution of the donor vascularised hand and face allograft in transplant rejection: An immunological perspective

IF 1.6 4区医学 Q4 IMMUNOLOGY

Transplant immunology Pub Date : 2024-03-21 DOI:10.1016/j.trim.2024.102035

Kavit R. Amin , James E. Fildes

{"title":"The contribution of the donor vascularised hand and face allograft in transplant rejection: An immunological perspective","authors":"Kavit R. Amin , James E. Fildes","doi":"10.1016/j.trim.2024.102035","DOIUrl":null,"url":null,"abstract":"<div><p>Overcoming immunological rejection remains a barrier to the safe adoption of Vascularised Composite Allotransplantation (VCA). To mitigate this risk, clinical protocols have been derived from solid organ transplantation, targeting recipient immunomodulation, yet VCA is unique. Face and hand composite allografts are composed of multiple different tissues, each with their own immunological properties.</p><p>Experimental work suggests that allografts carry variable numbers and populations of donor leukocytes in an organ specific manner. Ordinarily, these passenger leukocytes are transferred from the donor graft into the recipient circulation after transplantation. Whether alloantigen presentation manifests as acute allograft rejection or transplant tolerance is unknown. This review aims to characterise the immunological properties of the constituent parts of the donor face and hand, the potential fate of donor leukocytes and to consider theoretical graft specific interventions to mitigate early rejection.</p></div>","PeriodicalId":23304,"journal":{"name":"Transplant immunology","volume":"84 ","pages":"Article 102035"},"PeriodicalIF":1.6000,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0966327424000510/pdfft?md5=31b5d063aa981337fbd6b0a59b6b595a&pid=1-s2.0-S0966327424000510-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Transplant immunology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0966327424000510","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"IMMUNOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Overcoming immunological rejection remains a barrier to the safe adoption of Vascularised Composite Allotransplantation (VCA). To mitigate this risk, clinical protocols have been derived from solid organ transplantation, targeting recipient immunomodulation, yet VCA is unique. Face and hand composite allografts are composed of multiple different tissues, each with their own immunological properties.

Experimental work suggests that allografts carry variable numbers and populations of donor leukocytes in an organ specific manner. Ordinarily, these passenger leukocytes are transferred from the donor graft into the recipient circulation after transplantation. Whether alloantigen presentation manifests as acute allograft rejection or transplant tolerance is unknown. This review aims to characterise the immunological properties of the constituent parts of the donor face and hand, the potential fate of donor leukocytes and to consider theoretical graft specific interventions to mitigate early rejection.

查看原文本刊更多论文

供体血管化手部和面部同种异体移植在移植排斥反应中的作用：免疫学视角。

克服免疫排斥反应仍然是安全采用血管化复合器官移植（VCA）的障碍。为了降低这一风险，临床方案从实体器官移植中衍生出来，以受体免疫调节为目标，但 VCA 是独一无二的。面部和手部复合异体移植由多种不同组织组成，每种组织都有自己的免疫特性。实验工作表明，异体移植物以器官特异性方式携带不同数量和群体的供体白细胞。通常情况下，这些客体白细胞会在移植后从供体移植物转移到受体血液循环中。至于同种抗原呈递是表现为急性移植物排斥反应还是移植耐受，目前尚不清楚。本综述旨在描述供体面部和手部各组成部分的免疫学特性、供体白细胞的潜在命运，并从理论上探讨减轻早期排斥反应的特定移植物干预措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Transplant immunology 医学-免疫学

CiteScore

2.10

自引率

13.30%

发文量

198

审稿时长

48 days

期刊介绍： Transplant Immunology will publish up-to-date information on all aspects of the broad field it encompasses. The journal will be directed at (basic) scientists, tissue typers, transplant physicians and surgeons, and research and data on all immunological aspects of organ-, tissue- and (haematopoietic) stem cell transplantation are of potential interest to the readers of Transplant Immunology. Original papers, Review articles and Hypotheses will be considered for publication and submitted manuscripts will be rapidly peer-reviewed and published. They will be judged on the basis of scientific merit, originality, timeliness and quality.