Fusarium species central nervous system infection.

IF 3.6 3区医学 Q2 INFECTIOUS DISEASES

Current Opinion in Infectious Diseases Pub Date : 2024-06-01 Epub Date: 2024-03-18 DOI:10.1097/QCO.0000000000001009

Nora Strong, Luis Ostrosky-Zeichner

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引用次数: 0

Abstract

Purpose of review: Fusarium species are an increasingly important cause of meningitis and invasive disease in immunocompromised patients as well as in otherwise healthy patients as observed in two recent healthcare-associated outbreaks. This review summarizes recently published information on treatment and diagnosis of this infection.

Recent findings: Incidence of Fusarium species meningitis and invasive fusariosis are increasing. Molecular techniques are improving the speed of diagnosis. New antifungal agents in development show good in vitro activity against some Fusarium species. New technologies, including cerebrospinal fluid (CSF) filtration, may play a role in treatment of central nervous system (CNS) disease. Due to the continued prime importance of the host immune system in recovery, immunomodulatory treatments may play a role in treatment.

Summary: The overall incidence of CNS fusariosis is increasing with a continued poor prognosis, but new diagnostic and treatment modalities are in development which may offer improvements.

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镰刀菌中枢神经系统感染。

综述目的：镰刀菌是导致免疫力低下患者以及健康患者患脑膜炎和侵袭性疾病的一个日益重要的原因，这在最近两起与医疗保健有关的疫情中也有所体现。本综述总结了最近发表的有关这种感染的治疗和诊断信息：最近的发现：镰刀菌脑膜炎和侵袭性镰刀菌病的发病率正在上升。分子技术提高了诊断速度。正在开发的新型抗真菌药物对某些镰刀菌属具有良好的体外活性。包括脑脊液（CSF）过滤在内的新技术可能会在中枢神经系统（CNS）疾病的治疗中发挥作用。小结：中枢神经系统镰刀菌病的总发病率正在上升，预后仍然不佳，但正在开发的新诊断和治疗方法可能会有所改善。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Infectious Diseases 医学-传染病学

CiteScore

6.70

自引率

2.60%

发文量

121

审稿时长

6-12 weeks

期刊介绍： This reader-friendly, bimonthly resource provides a powerful, broad-based perspective on the most important advances from throughout the world literature. Featuring renowned guest editors and focusing exclusively on two topics, every issue of Current Opinion in Infectious Disease delivers unvarnished, expert assessments of developments from the previous year. Insightful editorials and on-the-mark invited reviews cover key subjects such as HIV infection and AIDS; skin and soft tissue infections; respiratory infections; paediatric and neonatal infections; gastrointestinal infections; tropical and travel-associated diseases; and antimicrobial agents.