Jordan N. Edwards , Madeline A. Whitney , Bradford B. Smith , Megan K. Fah , Skye A. Buckner Petty , Omar Durra , Kristen A. Sell-Dottin , Erica Portner , Erica D. Wittwer , Adam J. Milam
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引用次数: 0
Abstract
Background
This retrospective study evaluated the efficacy and safety of intraoperative methadone compared with short-acting opioids.
Methods
Patients undergoing cardiac surgery with cardiopulmonary bypass (n=11 967) from 2018 to 2023 from a single health system were categorised into groups based on intraoperative opioid administration: no methadone (Group O), methadone plus other opioids (Group M+O), and methadone only (Group M).
Results
Patients in Groups M and M+O had lower mean pain scores until postoperative day (POD) 7 compared with Group O after adjusting for covariates (P<0.01). Both Groups M and M+O had lower total opioid administered compared with Group O for all days POD0–POD6 (all P<0.001). The median number of hours until initial postoperative opioid after surgery was 2.55 (inter-quartile range [IQR]=1.07–5.12), 6.82 (IQR=3.52–12.98), and 7.0 (IQR=3.82–12.95) for Group O, Group M+O, and Group M, respectively. The incidence of postoperative complications did not differ between groups.
Conclusions
Intraoperative administration of methadone was associated with better pain control without significant side-effects after cardiac surgery.
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